Understand the source comparison
Best Research Peptides for PTSD Research: Feature Comparison
BPC-157 GABAergic modulation in basolateral amygdala Intraperitoneal 10 μg/kg daily ~4 hours GABA_A receptor density, freezing behavior in contextual fear conditioning Strongest signal in fear extinction protocols; requires IP administration for CNS penetratio
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- BPC-157
- GABAergic modulation in basolateral amygdala
- Intraperitoneal
- 10 μg/kg daily
- ~4 hours
- GABA_A receptor density, freezing behavior in contextual fear conditioning
- Strongest signal in fear extinction protocols; requires IP administration for CNS penetration
- Semax
- BDNF upregulation in hippocampus
- Intranasal
- 50 μg/day (divided bid)
- 60–90 minutes
- Hippocampal BDNF mRNA, dendritic spine density
- Best-documented neuroplasticity effects; intranasal route critical for direct CNS delivery
- Selank
- Enkephalinase inhibition, prolonged endogenous enkephalin activity
- Subcutaneous or intranasal
- 300–1000 μg/kg
- 20–30 minutes
- Plasma corticosterone rhythm, open-field locomotion
- Most consistent HPA axis normalization; anxiety reduction without sedation