Understand the source comparison
Best Peptides to Speed Up Metabolism Ranked: Mechanism Comparison
MK 677 GH secretagogue. IGF-1 elevation, lipolysis 8–12% Once daily Strong. Multiple Phase 2 trials Most reliable metabolic amplifier with reproducible IGF-1 response GHRP-2 GH secretagogue. Pulsatile GH release 6–10% 1–2× daily Moderate. Limited long-term dat
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- MK 677
- GH secretagogue. IGF-1 elevation, lipolysis
- 8–12%
- Once daily
- Strong. Multiple Phase 2 trials
- Most reliable metabolic amplifier with reproducible IGF-1 response
- GHRP-2
- GH secretagogue. Pulsatile GH release
- 6–10%
- 1–2× daily
- Moderate. Limited long-term data
- Effective for pulsatile protocols but requires precise timing
- CJC-1295 + Ipamorelin
- Extended GH release + selective GHS-R1a agonism
- 7–11%
- 2–3× weekly
- Moderate. Anecdotal > clinical
- Best for minimizing injection frequency in sustained protocols
- Thymalin
- Thymic restoration. Inflammatory cytokine modulation
- 3–6% (indirect)
- 5–10 day cycles
- Moderate. Eastern European clinical base
- Underappreciated for metabolic restoration in aging cohorts
- MOTS-c
- AMPK activation. Mitochondrial efficiency
- 5–8%
- Emerging. Preclinical + early human
- Mechanism is sound but human dose-response data still sparse
- Tesofensine
- Triple monoamine reuptake inhibition
- Strong. Phase 2 complete
- Metabolic effect tied to sympathetic activation. Not purely anabolic