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Best Peptides to Reduce Body Fat Percentage Ranked: Efficacy Comparison
Tirzepatide Dual GIP/GLP-1 receptor agonist—delays gastric emptying, amplifies insulin sensitivity, increases adipose lipolysis 20.9% body weight (89% adipose tissue) at 72 weeks Weekly subcutaneous injection Moderate (78–82% of weight lost is fat) Nausea, vom
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- Tirzepatide
- Dual GIP/GLP-1 receptor agonist—delays gastric emptying, amplifies insulin sensitivity, increases adipose lipolysis
- 20.9% body weight (89% adipose tissue) at 72 weeks
- Weekly subcutaneous injection
- Moderate (78–82% of weight lost is fat)
- Nausea, vomiting, diarrhoea (30–45% during titration)
- Strongest absolute fat loss, best for appetite-driven protocols
- CJC-1295/Ipamorelin
- GHRH analogue + ghrelin agonist—elevates pulsatile GH 2–3× baseline, activates hormone-sensitive lipase
- 6.4% body fat at 12 weeks (lean mass preserved)
- 5 days/week subcutaneous injection
- Excellent (98% lean mass retention)
- Mild water retention, transient numbness
- Best for anabolic preservation during deficit
- Tesofensine
- Triple monoamine reuptake inhibitor—raises sympathetic tone, increases RMR 10–15%, elevates NEAT
- 10.6% body weight at 24 weeks
- Daily oral capsule
- Moderate (lean mass not preferentially spared)
- Tachycardia, hypertension, insomnia
- Best for thermogenic effect without GI side effects
- Semaglutide
- GLP-1 receptor agonist—delays gastric emptying, reduces ghrelin rebound
- 14.9% body weight at 68 weeks
- Moderate (80–85% of weight lost is fat)
- Nausea, vomiting, constipation (25–35% during titration)
- Established safety data, lower cost than tirzepatide
- MK-677
- Oral ghrelin receptor agonist—stimulates GH and IGF-1 secretion
- 3.2% body fat at 16 weeks (appetite increase offsets deficit adherence)
- Excellent (anabolic signaling maintained)
- Significant appetite increase, mild oedema
- Only suitable when appetite control isn't limiting