Understand the source comparison
Best Peptides to Maintain Weight Loss Ranked: Full Comparison
Tirzepatide Dual GIP/GLP-1 agonist ~5 days Weekly Moderate (via insulin sensitivity) Very High Moderate positive (via nutrient partitioning) Best overall for multi-pathway maintenance. Highest regain prevention rate in clinical trials Semaglutide GLP-1 recepto
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Tirzepatide
- Dual GIP/GLP-1 agonist
- ~5 days
- Weekly
- Moderate (via insulin sensitivity)
- Very High
- Moderate positive (via nutrient partitioning)
- Best overall for multi-pathway maintenance. Highest regain prevention rate in clinical trials
- Semaglutide
- GLP-1 receptor agonist
- ~7 days
- Low
- High
- Neutral to slight negative
- Best for appetite-driven regain. Simpler mechanism but highly effective for ghrelin suppression
- CJC-1295/Ipamorelin
- GH secretagogue
- CJC: ~6–8 days / Ipa: ~2 hours
- 5x/week (evening)
- Significant positive (via lean mass retention)
- Best for metabolic rate preservation. Essential if lean mass loss is your primary regain driver
- Liraglutide
- ~13 hours
- Daily
- Moderate
- Neutral
- Effective but operationally inconvenient. Daily dosing reduces long-term adherence compared to weekly options
- Tesofensine
- Monoamine reuptake inhibitor
- ~8 days
- High (via CNS mechanism)
- Moderate positive (via thermogenesis)
- Emerging option with strong appetite suppression but limited long-term safety data. Not first-line