Understand the source comparison
Best Peptides to Increase Longevity Ranked: Evidence Comparison
Thymalin Thymic immune restoration via T-cell differentiation Moderate. Soviet longitudinal cohorts, modern replication limited 10mg daily × 10 days, quarterly cycles CD4+ T-cell count +22%, IL-6 reduction Strongest immune senescence reversal data; well-tolera
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- Thymalin
- Thymic immune restoration via T-cell differentiation
- Moderate. Soviet longitudinal cohorts, modern replication limited
- 10mg daily × 10 days, quarterly cycles
- CD4+ T-cell count +22%, IL-6 reduction
- Strongest immune senescence reversal data; well-tolerated
- Epitalon
- Telomerase activation and telomere lengthening
- Weak. Single-institution studies, no independent replication
- 5–10mg daily × 10–20 days, biannual
- Telomerase activity +33%, telomere length +9%
- Mechanistically sound but needs broader validation
- GHK-Cu
- Copper-dependent gene regulation for tissue repair and antioxidant enzyme expression
- Moderate. Dermatology and wound healing data; systemic longevity extrapolated
- 2–5mg subcutaneous 3× weekly or topical 0.1–1%
- Collagen synthesis genes upregulated 70%, inflammatory cytokines reduced
- Best-supported for localized tissue aging; systemic use less validated
- MOTS-c
- Mitochondrial-encoded AMPK activator for metabolic flexibility
- Weak. Rodent lifespan extension; human metabolic trials ongoing
- 5–15mg (exploratory human dosing)
- Insulin sensitivity +28%, fasting glucose −12% (rodent)
- Promising mitochondrial target but human longevity data absent
- Cartalax
- Vascular endothelial protection via eNOS upregulation
- Weak. Russian gerontology trials; minimal Western replication
- 20mg daily × 20 days, biannual
- Flow-mediated dilation +18%
- Addresses cardiovascular aging specifically; narrow focus