Understand the source comparison
Best Peptides to Increase HGH Naturally Ranked: Performance Comparison
Hexarelin 10–15× 20 minutes 2–3× daily High: cortisol/prolactin elevation, receptor desensitization after 4–6 weeks Strongest acute pulse but unsustainable long-term. Use for short research cycles CJC-1295 + Ipamorelin 5–8× (synergistic) 8 days (CJC) / 2 hours
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Hexarelin
- 10–15×
- 20 minutes
- 2–3× daily
- High: cortisol/prolactin elevation, receptor desensitization after 4–6 weeks
- Strongest acute pulse but unsustainable long-term. Use for short research cycles
- CJC-1295 + Ipamorelin
- 5–8× (synergistic)
- 8 days (CJC) / 2 hours (ipamorelin)
- 1–2× weekly
- Minimal: rare injection-site reactions, no appetite or cortisol effects
- Gold standard for sustained IGF-1 elevation with cleanest profile
- GHRP-2
- 5–8×
- Low: minimal appetite/cortisol, mild fluid retention possible
- Best balance for pulsatile research without appetite confound
- MK-677
- 2–4× (sustained)
- 24 hours
- Once daily (oral)
- Moderate: increased appetite, mild insulin resistance at >25mg
- Most convenient for long-term studies, oral administration
- Tesamorelin
- 3–5×
- 26–38 minutes
- Daily
- Low: injection-site reactions, rare hyperglycemia
- FDA-approved, safest regulatory profile for visceral fat research
- Sermorelin
- 2–4×
- 10 minutes
- 3× daily
- Minimal: short half-life limits side effects
- Outdated. Replaced by CJC-1295 in most protocols
- This table ranks peptides by clinical utility across research applications. Hexarelin produces the highest peak GH but isn't sustainable. CJC-1295 with ipamorelin delivers the most consistent IGF-1 elevation with the fewest complications. MK-677 trades peak efficacy for convenience. GHRP-2 remains the cleanest option for pulsatile studies. Tesamorelin is the only FDA-approved agent, limiting regulatory barriers in funded research.