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Best Peptides for Vaginal Dryness: Mechanism Comparison
Thymosin Alpha-1 (Thymalin) Immune modulation; reduces inflammatory cytokines (IL-6, TNF-alpha) that inhibit epithelial repair Not typically used topically 0.5–2.0 mg subcutaneous, twice weekly 4–6 weeks Best for cases where chronic inflammation is the primary
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- Thymosin Alpha-1 (Thymalin)
- Immune modulation; reduces inflammatory cytokines (IL-6, TNF-alpha) that inhibit epithelial repair
- Not typically used topically
- 0.5–2.0 mg subcutaneous, twice weekly
- 4–6 weeks
- Best for cases where chronic inflammation is the primary driver of atrophy. Works upstream of tissue damage
- BPC-157
- Angiogenesis via VEGF upregulation; increases mucosal blood flow and capillary density
- 2–5 mg per 30 mL gel base, applied nightly
- 200–500 mcg subcutaneous, daily
- 3–5 weeks
- Strongest evidence for vascular repair. Ideal when dryness is accompanied by poor tissue perfusion
- TB-500
- Actin regulation; accelerates keratinocyte migration and fibroblast proliferation during wound healing
- 3–6 mg per 30 mL gel base, applied nightly
- 2–5 mg subcutaneous, twice weekly
- 5–8 weeks
- Best for structural remodeling in cases of severe atrophy or post-radiation tissue damage