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Best Peptides for Ulcer Healing: Comparison
This table compares the three peptides with the most compelling preclinical evidence for accelerating ulcer repair. BPC-157 VEGF receptor activation → angiogenesis + fibroblast proliferation Oral or subcutaneous 88% ulcer reduction in 14 days (rat gastric ulce
No winner is assigned.
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- This table compares the three peptides with the most compelling preclinical evidence for accelerating ulcer repair.
- BPC-157
- VEGF receptor activation → angiogenesis + fibroblast proliferation
- Oral or subcutaneous
- 88% ulcer reduction in 14 days (rat gastric ulcer model, World J Gastroenterol 2014)
- Strongest evidence base for gastric ulcers specifically. Stable in acid, multiple injury models show consistent results
- TB-500
- Actin binding → enhanced epithelial cell migration + MMP upregulation
- Subcutaneous injection
- Accelerated mucosal healing in colitis model (Am J Physiol-GI 2010)
- Mechanism well-suited to ulcer closure, but most research focused on dermal/cardiac wounds. Gastric ulcer data limited
- KPV
- NF-kB inhibition → reduced IL-6, TNF-alpha, IL-1beta
- Oral (requires enteric coating)
- 40–50% reduction in colonic inflammation (IBD model, Inflamm Bowel Dis 2015)
- Best for inflammation-driven ulcers. Rapid peptidase degradation may limit oral bioavailability