Understand the source comparison
Best Peptides for Thyroid Weight Gain: Mechanism Comparison
| Peptide | Primary Mechanism | Thyroid Function Impact | Metabolic Rate Effect | Insulin Sensitivity | Evidence Quality | Professional Assessment ||—|—|—|—|—|—|| Thymalin | TSH pulse modulation, thyroid follicle protection | Direct. May enhance residual gland
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- | Peptide | Primary Mechanism | Thyroid Function Impact | Metabolic Rate Effect | Insulin Sensitivity | Evidence Quality | Professional Assessment ||—|—|—|—|—|—|| Thymalin | TSH pulse modulation, thyroid follicle protection | Direct. May enhance residual gland function | Indirect via improved T3/T4 output | Minimal | Preclinical models only, no RCTs | Relevant only for subclinical hypothyroidism with residual thyroid tissue. Not a replacement for levothyroxine || MK-677 | GH secretagogue (ghrelin receptor agonist) | None. Acts independently | +120 kcal/day via IGF-1 pathway | Neutral to slightly negative | Phase 2 RCTs in metabolic syndrome | Best option for restoring metabolic rate when TSH is controlled but energy expenditure remains suppressed || CJC-1295/Ipamorelin | Dual GHRH/GHRP agonism | None | +150–200 kcal/day estimated | Neutral | Phase 2 data, multiple trials | Similar to MK-677 but with pulsatile GH pattern closer to physiological secretion || Tesofensine | Triple monoamin