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Best Peptides for Telomere Lengthening: Evidence Comparison
Epithalamin Pineal extract; TERT upregulation 33.4% telomere length increase in elderly patients (12 months) Limited Russian trials; no large Western RCTs Research use only; not commercially available Strongest published human data for telomere lengthening, bu
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- Epithalamin
- Pineal extract; TERT upregulation
- 33.4% telomere length increase in elderly patients (12 months)
- Limited Russian trials; no large Western RCTs
- Research use only; not commercially available
- Strongest published human data for telomere lengthening, but replication needed
- Epitalon
- Synthetic Ala-Glu-Asp-Gly; TERT gene expression
- Telomerase restoration in senescent mice; modest CD4+ telomere gains in small human trial
- One published human study (n=26); primarily animal data
- Research peptide; unregulated
- Promising animal data, insufficient human evidence for definitive claims
- Thymalin
- Thymic peptide complex; oxidative stress reduction
- 2.8-fold telomerase increase in fibroblasts; reduced telomere shortening in lymphocytes
- Multiple Russian gerontology trials; no FDA-recognised studies
- Research use; not FDA-approved
- Strong evidence for immune cell telomere preservation; mechanism indirect
- MK-677
- GH secretagogue; IGF-1 elevation
- No direct telomerase activity demonstrated
- No telomere-focused trials published
- Research peptide (not approved for human use)
- IGF-1 effects theoretically beneficial but telomere link unproven
- Hexarelin
- GHRP; GH pulse stimulation
- No direct telomerase activity
- No telomere trials
- Research peptide
- Same limitations as MK-677; indirect pathway assumptions lack evidence