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Best Peptides for Sperm Quality: Research-Grade Comparison
L-Carnosine (dipeptide) Direct antioxidant + metal chelation DNA fragmentation index (DFI) Human trials show 20–25% DFI reduction in OAT patients Strong mechanistic rationale; safest option with clinical evidence MOTS-c Mitochondrial respiration optimization P
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- L-Carnosine (dipeptide)
- Direct antioxidant + metal chelation
- DNA fragmentation index (DFI)
- Human trials show 20–25% DFI reduction in OAT patients
- Strong mechanistic rationale; safest option with clinical evidence
- MOTS-c
- Mitochondrial respiration optimization
- Progressive motility + velocity
- Preclinical only; no human fertility trials
- Promising mechanism; limited data. Early-stage research
- Ipamorelin
- Selective GH secretion (no cortisol spike)
- Indirect: testosterone, LH/FSH balance
- No fertility-specific trials; GH studies show hormonal benefit
- Theoretical support; needs fertility endpoint validation
- MK 677
- Sustained IGF-1 elevation (40–90%)
- Indirect: anabolic environment for spermatogenesis
- IGF-1 trials robust; fertility trials absent
- High safety profile; indirect mechanism limits certainty
- Epithalon
- Telomerase activation + DNA repair signaling
- DNA integrity + cellular aging markers
- Preclinical gerontology studies; no direct sperm studies
- Intriguing for age-related fertility decline; speculative
- Thymalin
- Immune modulation + anti-inflammatory
- Indirect: reduces testicular inflammation
- Clinical use in immunity contexts; fertility link untested
- Plausible adjunct for immune-mediated infertility; needs trials