Understand the source comparison
Best Peptides for Slow Metabolism: Research Comparison
CJC-1295 (with DAC) GHRH receptor agonist. Extends GH pulse duration Subcutaneous injection 6–8 days Sustained IGF-1 elevation, enhanced lipolysis, improved insulin sensitivity 1–2 mg weekly Gold standard for restoring youthful GH dynamics without exogenous GH
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- CJC-1295 (with DAC)
- GHRH receptor agonist. Extends GH pulse duration
- Subcutaneous injection
- 6–8 days
- Sustained IGF-1 elevation, enhanced lipolysis, improved insulin sensitivity
- 1–2 mg weekly
- Gold standard for restoring youthful GH dynamics without exogenous GH administration
- Ipamorelin
- Ghrelin receptor agonist. Increases GH pulse amplitude
- 2 hours
- Selective GH release without cortisol/prolactin elevation
- 200–300 mcg 2–3x daily
- Ideal stacking partner for CJC-1295; minimal receptor desensitisation across repeated dosing
- MK 677 (Ibutamoren)
- Oral ghrelin mimetic. 24-hour GH secretion
- Oral capsule
- 24 hours
- Increases basal metabolic rate ~290 kcal/day, enhances mitochondrial function
- 25 mg daily
- Only orally active GH secretagogue; compliance advantage for long-term metabolic studies
- Tesofensine
- Triple monoamine reuptake inhibitor (norepinephrine, dopamine, serotonin)
- 8 days
- Beta-adrenergic thermogenesis, appetite suppression, leptin sensitivity restoration
- 0.25–0.5 mg daily
- Strongest evidence for sustained weight loss post-discontinuation; addresses both thermogenesis and hedonic eating
- GHRP-2
- Ghrelin receptor agonist. Broader receptor activity than ipamorelin
- 20–30 minutes
- GH release with moderate cortisol/prolactin elevation
- 100–300 mcg 2–3x daily
- More affordable than ipamorelin but less selective; useful for labs prioritising cost over precision