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Best Peptides for Rotator Cuff: Peptide Comparison
Before selecting peptides for rotator cuff research, compare their mechanisms, dosing complexity, and storage requirements. This table summarises the three categories most relevant to tendon healing models. BPC-157 Upregulates VEGF and FGF in damaged connectiv
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- Before selecting peptides for rotator cuff research, compare their mechanisms, dosing complexity, and storage requirements. This table summarises the three categories most relevant to tendon healing models.
- BPC-157
- Upregulates VEGF and FGF in damaged connective tissue; accelerates collagen type I deposition
- 200–500 mcg daily (subcutaneous)
- Lyophilised: −20°C; Reconstituted: 2–8°C, use within 28 days
- Gold standard for tendon healing research. Most published data, clearest mechanism. Requires cold chain integrity.
- TB-500
- Promotes actin upregulation and cell migration to injury sites; accelerates fibroblast and endothelial cell motility
- 2–5 mg weekly (subcutaneous or intramuscular)
- Complements BPC-157 by addressing migration speed rather than matrix quality. Best used in combination protocols.
- CJC-1295/Ipamorelin
- Stimulates endogenous GH and IGF-1 release; systemic anabolic signaling supports protein synthesis
- 100–200 mcg CJC + 200–300 mcg ipamorelin, 3× weekly
- Indirect tendon support through systemic IGF-1 elevation. Not a primary repair peptide but enhances metabolic environment for healing.
- MK-677 (ibutamoren)
- Ghrelin receptor agonist; oral GH secretagogue
- 25 mg daily (oral)
- Room temperature as capsules; no reconstitution required
- Simplifies administration in long-term studies but elevates cortisol alongside GH. May confound immune or stress endpoints.