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Best Peptides for Natural GH Elevation Research: Peptide Comparison
Before selecting a secretagogue for a specific research protocol, understand how mechanism, half-life, and side-effect profiles differ. The table below compares the four most commonly used GH-elevating peptides across the parameters that determine practical ut
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before selecting a secretagogue for a specific research protocol, understand how mechanism, half-life, and side-effect profiles differ. The table below compares the four most commonly used GH-elevating peptides across the parameters that determine practical utility in controlled studies.
- GHRP-2
- Ghrelin receptor agonist (GHS-R1a)
- 5–10× baseline
- 30–40 min
- Moderate cortisol/prolactin cross-reactivity
- 2–3× daily
- Highest peak GH. Best for protocols requiring maximum acute elevation. Cortisol spike limits use in metabolic studies.
- Ipamorelin
- Selective ghrelin receptor agonist
- 4–6× baseline
- Minimal cortisol/ACTH elevation
- Cleanest GHRP. Ideal for long-term studies where cortisol or prolactin interference would confound results. Lower peak GH than GHRP-2 but better selectivity.
- CJC-1295 (no DAC)
- GHRH receptor agonist
- Amplifies existing pulse 2–3×
- 30 min
- Minimal. No cortisol effects
- Must be stacked with a GHRP. Extends pulse duration rather than initiating release. Standard combo: 100 mcg GHRP + 30 mcg CJC per dose.
- MK-677 (Ibutamoren)
- Oral ghrelin mimetic
- Sustained 60–90% IGF-1 elevation
- 24 hours
- Increased appetite, mild water retention, slight insulin resistance
- 1× daily
- Only oral option. Flattens pulsatile GH rhythm but offers unmatched convenience for long-term trials. 25 mg daily is standard dose.