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Best Peptides for Multiple Sclerosis: Mechanism Comparison
Thymalin T-regulatory cell differentiation via thymulin receptor activation CD4+ T-cells in thymic tissue and peripheral circulation Minimal. Acts systemically on immune organs, not CNS-direct 10–30mg SC daily, 10-day cycles Short half-life (90–120 min); requi
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- Thymalin
- T-regulatory cell differentiation via thymulin receptor activation
- CD4+ T-cells in thymic tissue and peripheral circulation
- Minimal. Acts systemically on immune organs, not CNS-direct
- 10–30mg SC daily, 10-day cycles
- Short half-life (90–120 min); requires frequent dosing
- Cerebrolysin
- Neurotrophic factor signaling (BDNF, CNTF, NGF analogs) via Trk receptor activation
- Neurons, oligodendrocytes, astrocytes
- High. Low MW peptide fragments cross BBB efficiently
- 30mL IV infusion, 5 days/week for 4 weeks
- Multi-component formulation complicates mechanistic attribution
- Dihexa
- HGF/c-Met receptor potentiation (1000× amplification of endogenous HGF signal)
- Oligodendrocyte progenitor cells, mature oligodendrocytes
- High. Lipophilic modifications enable BBB crossing
- 1–5mg/kg SC, assessed 4–8 weeks post-treatment
- Limited human safety data; primarily animal model evidence