Understand the source comparison
Best Peptides for ME/CFS: Mechanism Comparison
Thymalin T-regulatory cell differentiation, IL-10/TGF-beta upregulation Immune dysregulation, chronic inflammation, Th17 dominance 5–10mg SC 2–3×/week, 8–12 weeks Human RCTs in autoimmune conditions; reduced IL-17 40–55% Strongest for patients with documented
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- Thymalin
- T-regulatory cell differentiation, IL-10/TGF-beta upregulation
- Immune dysregulation, chronic inflammation, Th17 dominance
- 5–10mg SC 2–3×/week, 8–12 weeks
- Human RCTs in autoimmune conditions; reduced IL-17 40–55%
- Strongest for patients with documented Treg deficiency and elevated pro-inflammatory cytokines
- Cerebrolysin
- Neurotrophic factor delivery (BDNF/NGF mimetic), Trk receptor activation
- Cognitive impairment, reduced synaptic plasticity, neuroinflammation
- 10–30mL IV 5×/week, 4 weeks
- Meta-analysis of 1,800+ patients; 15–22% cognitive improvement
- Best for brain fog and executive function deficits; requires IV administration
- MK-677
- Growth hormone secretagogue, IGF-1 elevation, sleep architecture improvement
- Mitochondrial dysfunction, fragmented sleep, reduced cellular repair
- 10–25mg oral daily, 8–12 weeks
- RCTs showing 40–90% IGF-1 increase, 50% REM sleep improvement
- Accessible oral dosing; monitor glucose and insulin sensitivity
- Dihexa
- HGF mimetic, c-Met receptor agonist, synaptogenesis promotion
- Cognitive dysfunction, impaired neuroplasticity
- 1–5mg SC daily or every other day
- Preclinical data; 5–7× synaptogenic potency vs BDNF
- Experimental; limited human data but promising mechanism
- CJC-1295/Ipamorelin
- Dual GHRH/ghrelin agonism, physiological GH pulsatility
- Mitochondrial dysfunction, muscle fatigue, inflammatory cytokine elevation
- 100–200mcg each SC before bed, 5×/week
- Human data in aging and GH deficiency; improves lean mass and recovery markers
- Preferred over exogenous GH for maintaining endogenous pulsatility