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Best Peptides for Male Infertility: Mechanism Comparison
| Peptide | Primary Mechanism | Target Cell Type | Clinical Evidence | Typical Dosing Protocol | Time to Sperm Detection | Professional Assessment ||—|—|—|—|—|—|| Human Chorionic Gonadotropin (hCG) | Mimics LH; stimulates Leydig cells to produce intratesticula
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- | Peptide | Primary Mechanism | Target Cell Type | Clinical Evidence | Typical Dosing Protocol | Time to Sperm Detection | Professional Assessment ||—|—|—|—|—|—|| Human Chorionic Gonadotropin (hCG) | Mimics LH; stimulates Leydig cells to produce intratesticular testosterone | Leydig cells (testosterone synthesis) | 54% success rate as monotherapy; 74% combined with FSH (2017 meta-analysis, Andrology) | 1,500–3,000 IU SC 2–3x/week | Median 6 months (monotherapy); 4.2 months (combined therapy) | First-line choice for secondary hypogonadism; gold standard for restoring intratesticular testosterone || Recombinant FSH (rFSH) | Stimulates Sertoli cells; supports germ cell development and seminiferous tubule integrity | Sertoli cells (sperm maturation support) | Significantly higher sperm concentrations when combined with hCG vs hCG alone (2015 RCT, Fertility and Sterility) | 75–150 IU SC 3x/week | Median 4–6 months when combined with hCG | Essential for men with prolonged hypogonadism or pri