Understand the source comparison
Best Peptides for Low Sperm Count: Mechanism Comparison
Kisspeptin-10 Restores GnRH pulsatility, increases LH/FSH Secondary hypogonadism, hypothalamic dysfunction 1–4mcg/kg pulsed every 90 min or 6.4nmol/kg bolus 8–16 weeks for hormonal normalization, 6–12 months for sperm improvement Most direct HPG axis intervent
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Kisspeptin-10
- Restores GnRH pulsatility, increases LH/FSH
- Secondary hypogonadism, hypothalamic dysfunction
- 1–4mcg/kg pulsed every 90 min or 6.4nmol/kg bolus
- 8–16 weeks for hormonal normalization, 6–12 months for sperm improvement
- Most direct HPG axis intervention. Requires pulsatile dosing for efficacy
- Gonadorelin
- Replaces deficient GnRH, stimulates pituitary LH/FSH release
- Kallmann syndrome, congenital GnRH deficiency
- 25–50ng/kg pulsed via pump every 90–120 min
- 3–6 months to first sperm appearance, 12–18 months to therapeutic counts
- Gold standard for GnRH deficiency but device-dependent and high discontinuation
- MK-677
- GH secretagogue, increases IGF-1 and testosterone indirectly
- Metabolic dysfunction, low IGF-1, age-related decline
- 12.5–25mg oral daily
- 4–8 weeks for metabolic markers, 12–24 weeks for sperm parameters
- Best systemic metabolic support. Doesn't target HPG axis directly
- Hexarelin
- GH secretagogue with stronger pituitary response than MK-677
- Similar to MK-677 but for shorter intervention windows
- 100–200mcg subcutaneous 2x daily
- 2–4 weeks for GH/IGF-1 rise, 8–16 weeks for downstream fertility effects
- Higher peak GH but requires strict dosing schedule
- Thymalin
- Immune modulation, reduces testicular inflammation
- Autoimmune orchitis, elevated seminal leukocytes
- 5–10mg intramuscular 1–2x weekly
- 6–12 weeks for immune markers, variable sperm response
- Addresses inflammation but not hormonal causes
- TB-500
- Vascular repair, angiogenesis in testicular tissue
- Varicocele, post-surgical atrophy, microvascular insufficiency
- 2–5mg subcutaneous 2x weekly
- 4–8 weeks for tissue markers, 12–24 weeks for sperm improvement
- Indirect support through improved blood flow. Not first-line