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Best Peptides for Low Sex Drive Men: Mechanism Comparison
PT-141 (Bremelanotide) Melanocortin-3 and Melanocortin-4 receptor agonist in hypothalamus. Directly increases sexual arousal independent of testosterone 30–60 minutes subcutaneous 4–6 hours 0.75–2.0mg subcutaneous 45 minutes before activity Most direct libido
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- PT-141 (Bremelanotide)
- Melanocortin-3 and Melanocortin-4 receptor agonist in hypothalamus. Directly increases sexual arousal independent of testosterone
- 30–60 minutes subcutaneous
- 4–6 hours
- 0.75–2.0mg subcutaneous 45 minutes before activity
- Most direct libido enhancement. Works regardless of androgen status, bypasses erectile mechanisms entirely
- Kisspeptin-10
- GPR54 receptor agonist on GnRH neurons. Restores pulsatile gonadotropin release and normalises testosterone production
- 60–90 minutes IV or subcutaneous
- 6–12 hours (LH elevation), 24–48 hours (testosterone rise)
- 0.24–4.0 nmol/kg IV or 1.0 nmol/kg subcutaneous 2–3× weekly
- Best for secondary hypogonadism with intact testicular function. Receptor desensitisation limits daily use
- Gonadorelin (Synthetic GnRH)
- Direct GnRH replacement. Stimulates LH and FSH release when hypothalamic signaling is suppressed or absent
- 30–60 minutes pulsatile delivery
- Pulsatile protocol maintains steady-state gonadotropin levels
- 25–150 mcg subcutaneous every 90–120 minutes via pump, or 500–1000 mcg twice daily bolus
- Most effective for HPTA restoration after anabolic steroid use. Impractical dosing without infusion pump