Understand the source comparison
Best Peptides for Lean Bulk: Research-Grade Comparison
CJC-1295 (no DAC) + Ipamorelin GHRH analog + ghrelin agonist (pulsatile GH release) 70–85% above baseline 2–3× daily No desensitisation Multiple trials show 4–6% lean mass gain over 12–16 weeks Gold standard for bulking. Mimics natural GH rhythm without shutdo
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- CJC-1295 (no DAC) + Ipamorelin
- GHRH analog + ghrelin agonist (pulsatile GH release)
- 70–85% above baseline
- 2–3× daily
- No desensitisation
- Multiple trials show 4–6% lean mass gain over 12–16 weeks
- Gold standard for bulking. Mimics natural GH rhythm without shutdown
- MK-677 (Ibutamoren)
- Oral ghrelin mimetic (sustained GH elevation)
- 90–120% above baseline
- 1× daily
- No cycling needed
- Merck Phase II: 8.8% lean mass increase over 12 months
- Best for prolonged bulk phases. No injection required, no receptor fatigue
- Hexarelin
- Potent GH secretagogue (peak amplitude)
- 150–200% peaks (short duration)
- 1–2× daily
- Required (14 days on, 14 days off)
- Limited long-term data. Rapid desensitisation limits hypertrophy application
- Highest peak GH response but impractical for sustained bulking due to receptor downregulation
- CJC-1295 DAC
- Modified GHRH with extended half-life
- 60–75% sustained
- 2× weekly
- Comparable to non-DAC version with less frequent dosing
- Convenient for compliance but blunted GH peaks versus pulsatile protocols
- GHRP-2
- Ghrelin receptor agonist
- 50–70% above baseline
- Mild desensitisation after 8–12 weeks
- Early trials showed modest lean mass gains (2–4%) over 8 weeks
- Less potent than Ipamorelin with higher cortisol response. Rarely first-line choice