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Best Peptides for Knee Pain: Evidence Comparison
| Peptide | Primary Mechanism | Injury Type Target | Typical Dose Range | Administration Frequency | Evidence Strength | Professional Assessment ||—|—|—|—|—|—|| BPC-157 | VEGF-mediated angiogenesis, tendon-to-bone healing | Ligament tears, tendon microtears, p
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- | Peptide | Primary Mechanism | Injury Type Target | Typical Dose Range | Administration Frequency | Evidence Strength | Professional Assessment ||—|—|—|—|—|—|| BPC-157 | VEGF-mediated angiogenesis, tendon-to-bone healing | Ligament tears, tendon microtears, post-surgical repair | 200–500 mcg | Daily or twice daily | Multiple rodent studies, limited human trials | Best for vascular-dependent tissue repair; not cartilage-specific || TB-500 | Actin-binding cell mobilization, anti-inflammatory cytokine suppression | Acute inflammation, muscle strains, synovial inflammation | 2–5 mg | Twice weekly | Robust preclinical data, anecdotal human use | Strongest anti-inflammatory profile; use in acute phase || GHK-Cu | Collagen type I/III synthesis, fibroblast proliferation | Osteoarthritis, cartilage degradation, chronic joint remodeling | 1–3 mg | 2–3 times weekly | In vitro collagen studies, limited in vivo joint data | Only peptide targeting cartilage matrix directly; long-term use required |