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Best Peptides for Keloid Treatment: Research Evidence Comparison
Thymosin Beta-4 (TB-4) Downregulates TGF-β1, inhibits mast cell degranulation, promotes organized angiogenesis Active (early-stage) Reduced keloid fibroblast proliferation by 40% at 100 μg/mL (Journal of Investigative Dermatology) 50–100 μg/mL topical Stronges
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- Thymosin Beta-4 (TB-4)
- Downregulates TGF-β1, inhibits mast cell degranulation, promotes organized angiogenesis
- Active (early-stage)
- Reduced keloid fibroblast proliferation by 40% at 100 μg/mL (Journal of Investigative Dermatology)
- 50–100 μg/mL topical
- Strongest evidence for early intervention—targets the inflammatory driver directly
- GHK-Cu (Copper Peptide)
- Increases matrix metalloproteinase (MMP) activity, promotes collagen breakdown and remodeling
- Mature (late-stage)
- Increased MMP-2 activity by 3.2-fold in keloid fibroblasts (Archives of Dermatological Research)
- 1–3 mM topical
- Best option for established keloids where the goal is remodeling rather than prevention
- BPC-157
- Modulates VEGF, reduces IL-6 and inflammatory cytokines, supports vascular normalization
- Reduced IL-6 expression by 60% in wound models (Journal of Physiology and Pharmacology)
- 1–10 μg/mL subcutaneous or topical
- Limited keloid-specific data but strong anti-inflammatory profile—worth exploring in combination protocols