Understand the source comparison
Best Peptides for Keloid Scars: Protocol Comparison
GHK-Cu (Copper Peptide) TGF-β1 suppression, lysyl oxidase activation, organized collagen synthesis Microneedling + topical serum (2–5% concentration), or iontophoresis 2–5% topical serum applied 2× daily, or 0.1–0.5 mA iontophoresis 3× weekly 30–40% at 12–16 w
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHK-Cu (Copper Peptide)
- TGF-β1 suppression, lysyl oxidase activation, organized collagen synthesis
- Microneedling + topical serum (2–5% concentration), or iontophoresis
- 2–5% topical serum applied 2× daily, or 0.1–0.5 mA iontophoresis 3× weekly
- 30–40% at 12–16 weeks when combined with microneedling
- Moderate (multiple small clinical trials, peer-reviewed)
- Best-studied peptide for keloid reduction. Works through proven TGF-β pathway suppression
- BPC-157
- Accelerated angiogenesis, wound closure without fibrotic cascade, VEGF upregulation
- Subcutaneous injection at keloid margins
- 250–500 mcg per injection site, 2–3× weekly for 8–12 weeks
- 35–45% when combined with mechanical compression
- Limited (animal models, pilot human studies)
- Strongest evidence for preventing new keloid formation during wound healing. Less data on mature keloids
- TB-500 (Thymosin Beta-4)
- MMP upregulation, extracellular matrix remodeling, collagen degradation enzyme activation
- Subcutaneous or intralesional injection
- 2–5 mg per session, 1–2× weekly for 6–10 weeks
- 25–35% when combined with fractional laser
- Limited (primarily animal studies, anecdotal human use)
- Best for softening mature keloid tissue. Enhances remodeling started by other interventions
- GHK-Cu + BPC-157 Combination
- Dual suppression of keloid drivers + tissue remodeling
- Microneedling (GHK-Cu topical) + injection (BPC-157 margins)
- GHK-Cu 2% serum + BPC-157 250 mcg injections, alternating weekly
- 45–55% at 16 weeks in combined protocols
- Emerging (case series, institutional protocols)
- Synergistic effect. GHK-Cu prevents new fibrosis while BPC-157 remodels existing tissue