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Best Peptides for Increasing Growth Hormone Naturally: Research Protocol Comparison
| Peptide | Mechanism | Half-Life | Typical Dosing Protocol | Secondary Hormonal Effects | Desensitization Risk | Research Application ||—|—|—|—|—|—|| CJC-1295 (with DAC) | GHRH analog | 6–8 days | 1–2 mg once weekly | Minimal—GH-specific | Very low | Long-dur
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- | Peptide | Mechanism | Half-Life | Typical Dosing Protocol | Secondary Hormonal Effects | Desensitization Risk | Research Application ||—|—|—|—|—|—|| CJC-1295 (with DAC) | GHRH analog | 6–8 days | 1–2 mg once weekly | Minimal—GH-specific | Very low | Long-duration studies requiring sustained GH elevation and minimal administration frequency || Ipamorelin | Selective ghrelin agonist | ~2 hours | 200–300 mcg 2–3× daily | None—highly selective for GH | Low | Studies requiring isolated GH effects without cortisol or prolactin confounds || Hexarelin | Potent ghrelin agonist | ~70 minutes | 100–200 mcg 2–3× daily | Moderate cortisol/prolactin elevation, cardiac receptor activation | High (4–8 weeks) | Acute GH response studies, short-duration protocols under 4 weeks || GHRP-2 | First-generation ghrelin agonist | ~30 minutes | 100–300 mcg 2–3× daily | Moderate—cortisol and prolactin elevation (40–60% above baseline) | Moderate | Broad metabolic studies where ghrelin pathway effects beyond GH