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Best Peptides for GAD Generalized Anxiety: Mechanism Comparison
Thymalin Thymic immunomodulation. Reduces IL-6, TNF-alpha, cortisol Peripheral cytokine suppression → reduced microglial activation 6–8 weeks (two cycles) 1–2mg subcutaneous, 5 consecutive days, 25-day rest Best for immune-driven anxiety with elevated inflamma
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- Thymalin
- Thymic immunomodulation. Reduces IL-6, TNF-alpha, cortisol
- Peripheral cytokine suppression → reduced microglial activation
- 6–8 weeks (two cycles)
- 1–2mg subcutaneous, 5 consecutive days, 25-day rest
- Best for immune-driven anxiety with elevated inflammatory markers
- P21
- BDNF mimetic. Enhances hippocampal neurogenesis and dendritic growth
- TrkB receptor activation → increased BDNF signaling
- 10–14 days minimum, optimal 8–12 weeks
- 5–20mg subcutaneous, once weekly
- Best for anxiety linked to hippocampal atrophy or impaired fear extinction
- Dihexa
- HGF pathway agonist. Drives synaptogenesis in prefrontal cortex
- c-Met receptor activation → synaptic density restoration
- 4–6 weeks for functional connectivity improvement
- 1–5mg oral, daily
- Best for anxiety with documented prefrontal thinning or cognitive impairment