Understand the source comparison
Best Peptides for Frozen Embryo Transfer: Protocol Comparison
Before selecting a peptide protocol, compare mechanism of action, administration requirements, and the specific FET challenge each addresses. Thymalin T-regulatory cell expansion, immune tolerance 10mg SC daily × 10 days 10–12 days Recurrent implantation failu
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before selecting a peptide protocol, compare mechanism of action, administration requirements, and the specific FET challenge each addresses.
- Thymalin
- T-regulatory cell expansion, immune tolerance
- 10mg SC daily × 10 days
- 10–12 days
- Recurrent implantation failure, elevated NK cells
- Strongest evidence for immune-mediated implantation failure; requires consistent daily dosing
- MK 677
- GH secretagogue, IGF-1 elevation
- 12.5–25mg oral daily
- 14–21 days
- Thin endometrium (<7mm), poor proliferative response
- Effective for thickness but requires 2+ weeks; monitor glucose in insulin-resistant patients
- BPC-157
- Angiogenesis (VEGF upregulation)
- 250–500mcg SC daily
- 10–14 days
- Elevated uterine artery PI, vascular insufficiency
- Investigational for FET; case reports show promise but limited controlled data
- CJC-1295 + Ipamorelin
- Sustained GH release, metabolic support
- 100mcg each SC every 3–4 days
- Suboptimal endometrial quality despite adequate thickness
- Addresses metabolic/mitochondrial aspects beyond thickness alone
- Dihexa
- HGF receptor potentiation
- 1–5mg oral daily
- 7–10 days
- Poor secretory transformation
- Mechanism sound but clinical FET data limited; experimental protocol
- Cerebrolysin
- BDNF pathway, decidualization support
- 5–10mL IM 2–3× weekly
- Thin endometrium unresponsive to estrogen
- Primarily neurological use; FET application remains off-label and investigational