Understand the source comparison
Best Peptides for Endurance: Performance Comparison
MOTS-c Mitochondrial biogenesis via AMPK activation Increased oxidative capacity and fatty acid metabolism 30% improvement in time to exhaustion (mouse model) 5–15mg SC 2–3×/week Well-tolerated in animal studies; human safety data limited SS-31 (Elamipretide)
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- MOTS-c
- Mitochondrial biogenesis via AMPK activation
- Increased oxidative capacity and fatty acid metabolism
- 30% improvement in time to exhaustion (mouse model)
- 5–15mg SC 2–3×/week
- Well-tolerated in animal studies; human safety data limited
- SS-31 (Elamipretide)
- Cardiolipin stabilization in mitochondrial membrane
- Reduced ATP leak, improved VO2 efficiency
- +28m 6-minute walk distance in heart failure patients
- 2–5mg SC daily or 0.25–4mg/kg IV
- Phase 2 trials show good tolerability; injection site reactions possible
- EPO Analogs
- Erythropoiesis (red blood cell production)
- Increased oxygen-carrying capacity
- 6% faster 10K time (recreational runners)
- 50–150 IU/kg SC 2–3×/week
- High risk: thrombosis if hematocrit >54%; WADA-prohibited
- Ipamorelin + CJC-1295
- GH secretagogue (pulsatile and sustained release)
- Faster recovery between training sessions
- No direct VO2 max improvement; reduced recovery time documented
- 100–200mcg each SC before bed
- Mild: hunger, water retention, paresthesia; long-term GH effects unclear
- Hexarelin
- GH and cortisol release via ghrelin receptor
- Recovery acceleration, controversial cardioprotection
- No controlled endurance trials; anecdotal reports only
- 100mcg SC 1–2×/daily
- Cortisol elevation and receptor desensitization limit long-term use