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Best Peptides for Diabetic Ulcers: Mechanism Comparison
BPC-157 VEGF-R2 upregulation → angiogenesis, collagen synthesis Subcutaneous peri-wound or topical 250–500 mcg/day or every other day Preclinical + case reports Best for wounds with poor granulation tissue and low vascularity. Targets the angiogenic deficit di
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- BPC-157
- VEGF-R2 upregulation → angiogenesis, collagen synthesis
- Subcutaneous peri-wound or topical
- 250–500 mcg/day or every other day
- Preclinical + case reports
- Best for wounds with poor granulation tissue and low vascularity. Targets the angiogenic deficit directly
- TB-500 (Thymosin Beta-4)
- Actin-binding → keratinocyte/fibroblast migration, reduces inflammation
- Subcutaneous peri-wound
- 2–5 mg, 2–3×/week for 4–6 weeks
- Preclinical + small clinical case series
- Best for stalled wounds in chronic inflammation phase. Promotes cell migration when integrin signaling is impaired
- GHK-Cu (Copper Peptide)
- MMP regulation, collagen I/III synthesis, fibroblast activation
- Topical gel or impregnated dressing
- 0.05–0.1% concentration, daily application
- FDA-cleared dressings + RCTs
- Best for superficial ulcers (Grade 1–2). Normalizes extracellular matrix remodeling and reduces excessive MMP degradation