Understand the source comparison
Best Peptides for Detox: Full Comparison
The table below compares peptides and amino acid derivatives with documented roles in detoxification pathways. Covering mechanism, clinical dosing ranges, and practical limitations. N-Acetylcysteine (NAC) Provides cysteine for glutathione synthesis; restores P
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- The table below compares peptides and amino acid derivatives with documented roles in detoxification pathways. Covering mechanism, clinical dosing ranges, and practical limitations.
- N-Acetylcysteine (NAC)
- Provides cysteine for glutathione synthesis; restores Phase II conjugation capacity
- 600–1200mg twice daily (oral) or 150mg/kg IV loading in acute toxicity
- Oral: 6–10% (improved with liposomal delivery)
- Sulfurous odor; GI upset in 15–20% of users
- Gold standard for GSH restoration. Clinical evidence across acetaminophen overdose, NAFLD, and chronic toxin exposure
- Reduced L-Glutathione (GSH)
- Direct supply of the GSH tripeptide for conjugation reactions
- 250–500mg daily (liposomal preferred)
- Oral: <5% unless liposomal (then 25–30%)
- Degraded by intestinal peptidases; liver must reassemble from amino acids
- Less effective than precursor supply (NAC + glycine); best used in liposomal form
- Glycine
- Required for GSH synthesis and bile acid conjugation (glycocholic acid)
- 5g twice daily
- Oral: >95% (non-essential amino acid)
- Large dose volume; may cause mild sedation in evening doses
- Underutilised despite strong evidence. Restores hepatic GSH and improves bile flow
- Carnosine
- Inhibits AGE formation; supports proteasomal degradation of glycated proteins
- 500mg twice daily
- Oral: 70–80%
- Degraded by carnosinase enzyme; shorter half-life than other peptides
- Effective for glycation-related toxin buildup. Best in diabetic or high-glucose contexts
- Taurine
- Supports bile acid conjugation; enhances Phase II sulfation pathways
- 1.5–3g daily
- Oral: >90%
- Requires consistent dosing to maintain bile flow improvements
- Essential in chronic liver disease; supports both conjugation and excretion
- Nicotinamide Riboside (NMN/NR)
- NAD+ precursor; activates sirtuin-1 and autophagy pathways
- 250–500mg daily
- Oral: 40–60% (converted to NAD+ in cells)
- Expensive; benefits plateau after 4–6 weeks at steady dose
- Strong mitochondrial biogenesis signal. Best for toxin-induced mitochondrial damage