Understand the source comparison
Best Peptides for Chronic Lyme: Mechanism Comparison
Thymalin Thymic T-cell maturation, IL-2 upregulation Th2 immune skewing, lymphopenia 10–20mg IM every 3–5 days Animal + human observational Strongest immune restoration data. No Lyme-specific trials Cerebrolysin Neurotrophic factor delivery (BDNF, NGF) Microgl
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- Thymalin
- Thymic T-cell maturation, IL-2 upregulation
- Th2 immune skewing, lymphopenia
- 10–20mg IM every 3–5 days
- Animal + human observational
- Strongest immune restoration data. No Lyme-specific trials
- Cerebrolysin
- Neurotrophic factor delivery (BDNF, NGF)
- Microglial activation, white matter lesions
- 10–30mL IV 5 days/week × 4 weeks
- Multiple RCTs in cognitive impairment
- Best-studied neuroprotective peptide. Not Lyme-specific
- KPV
- NF-kB inhibition, anti-inflammatory signaling
- Gut barrier dysfunction, cytokine elevation
- 500mcg–1mg SC daily
- Animal models, limited human case reports
- Mechanistically sound for leaky gut. Minimal human data
- Dihexa
- HGF receptor upregulation, synaptogenesis
- Synaptic damage from neurotoxins
- 5mg orally daily
- Preclinical only
- Potent cognitive enhancer. Zero human safety trials
- BPC-157
- VEGF upregulation, nitric oxide modulation
- Tissue repair, joint inflammation
- 250–500mcg SC twice daily
- Animal studies only
- Well-tolerated in anecdotal use. No human RCTs
- P21
- CNTF-derived cholinergic support
- Cholinergic and dopaminergic disruption
- 10–20mg SC twice weekly
- Observational/anecdotal
- Subjective cognitive gains. No formal trials