Understand the source comparison
Best Peptides for Biohacking, Longevity & Performance: Protocol Comparison
Before designing a peptide stack, understand how compound classes interact and where they belong in a protocol hierarchy. GH Secretagogues (CJC-1295/Ipamorelin) GHRH/ghrelin receptor agonism → pulsatile GH release 3–5×/week (CJC once weekly if DAC-modified) Pa
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before designing a peptide stack, understand how compound classes interact and where they belong in a protocol hierarchy.
- GH Secretagogues (CJC-1295/Ipamorelin)
- GHRH/ghrelin receptor agonism → pulsatile GH release
- 3–5×/week (CJC once weekly if DAC-modified)
- Pair GHRH analogues (night) with ghrelin mimetics (morning) for additive pulse amplitude
- Foundation of performance stacks. Addresses anabolic signalling, recovery, sleep architecture. Requires insulin sensitivity monitoring when combined with metabolic peptides.
- Neuroprotective Peptides (Cerebrolysin, Dihexa, P21)
- BDNF/NGF mimicry, HGF/c-Met activation → synaptogenesis
- 2–3×/week (Cerebrolysin), daily (Dihexa, P21)
- Works independently. No receptor competition with GH or metabolic compounds
- CNS resilience layer. Essential for longevity protocols prioritising cognitive preservation. Dosing based on preclinical research; human trials limited.
- Metabolic Modulators (Tesofensine, Survodutide, SLU-PP-332)
- AMPK activation, GLP-1/glucagon agonism, REV-ERB modulation → fat oxidation, insulin sensitivity
- Daily (Tesofensine 0.25–0.5mg), weekly (GLP-1 agonists), pre-training (SLU-PP-332)
- SLU-PP-332 + GH secretagogues amplifies mitochondrial biogenesis. Avoid stacking multiple GLP-1 agonists without glucose monitoring.
- Recomposition protocols depend on this class. But metabolic health (fasting glucose, HbA1c, lipid panels) must be baseline-normal before stacking with GH compounds.
- Immune and Longevity Peptides (Thymalin, Cartalax, KPV)
- Thymic peptide regulation, telomere maintenance signalling, anti-inflammatory modulation
- 2×/week (Thymalin), daily or EOD (Cartalax, KPV)
- Thymalin + GH secretagogues. Immune function declines with age parallel to GH decline; addressing both extends healthspan metrics
- Longevity stacks incomplete without immune system targeting. Cellular senescence management requires both growth factor optimisation and immune surveillance restoration.
- Lipotropic Formulations (Lipo-C)
- Methionine, inositol, choline → hepatic fat mobilisation, methyl donor support
- 2–3×/week
- Combines well with GLP-1 agonists. Supports liver function during fat oxidation phases
- Supportive compound, not primary driver. Useful during aggressive recomposition to prevent hepatic steatosis from rapid lipolysis.