Understand the source comparison
Best Peptides for ADHD: Research Comparison
Cerebrolysin BDNF-like neurotrophic signaling Synaptic plasticity, dendritic arborisation Improved cognitive flexibility, working memory retention 10–30 mL IV daily (clinical); 1–5 mg/kg subcutaneous (research) Strongest evidence for synaptic remodeling. Requi
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- Cerebrolysin
- BDNF-like neurotrophic signaling
- Synaptic plasticity, dendritic arborisation
- Improved cognitive flexibility, working memory retention
- 10–30 mL IV daily (clinical); 1–5 mg/kg subcutaneous (research)
- Strongest evidence for synaptic remodeling. Requires repeated dosing over weeks
- Dihexa
- HGF receptor (c-Met) activation
- Dendritic spine formation, hippocampal synaptogenesis
- Enhanced cognitive flexibility, sustained attention (rodent models)
- 0.1–1 mg/kg oral or subcutaneous
- Most potent per-dose synaptogenic compound. Limited human trial data
- P21
- CREB phosphorylation and gene transcription
- Memory consolidation, hippocampal-prefrontal connectivity
- Improved pattern separation, declarative memory (rodent models)
- 1–10 mg subcutaneous
- Targets consolidation deficits. Less acute effect than synaptic modulators
- Thymalin
- Immune-neuroendocrine modulation via thymic peptides
- Cytokine regulation, neuroinflammation reduction
- Reduced inflammatory markers, indirect cognitive support (aging models)
- 5–10 mg intramuscular or subcutaneous
- Addresses immune-cognitive crosstalk. Speculative in ADHD contexts
- MK-677
- Ghrelin receptor agonism (GH secretagogue)
- IGF-1 elevation, dopamine receptor sensitization
- Improved sleep quality, white matter integrity (adolescent studies)
- 10–25 mg oral daily
- Non-peptide but functionally similar. Supports long-term brain health
- SLU-PP-332
- ERR-gamma agonism
- Mitochondrial biogenesis, neuronal ATP production
- Enhanced endurance, metabolic efficiency (muscle models. CNS effects hypothetical)
- Experimental. 10–50 mg oral in metabolic studies
- Emerging compound. Mechanistic fit for ADHD energy dysregulation