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Best Peptides for Achilles Tendinitis: Mechanism Comparison
BPC-157 VEGF receptor upregulation, angiogenesis 200–500 mcg/day (scaled to bodyweight) Once daily 14-day acceleration in tendon-to-bone healing; improved collagen alignment (J Orthop Res, 2011) Strongest evidence for direct tendon repair; localized injection
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- BPC-157
- VEGF receptor upregulation, angiogenesis
- 200–500 mcg/day (scaled to bodyweight)
- Once daily
- 14-day acceleration in tendon-to-bone healing; improved collagen alignment (J Orthop Res, 2011)
- Strongest evidence for direct tendon repair; localized injection near injury site recommended
- TB-500
- Actin polymerization, cell migration
- 4–10 mg/kg twice weekly
- Twice weekly
- Increased tensile strength and collagen organization in surgically repaired tendons (University of Illinois)
- Best for structural repair; longer dosing protocol (4+ weeks) required for maximal effect
- GHK-Cu
- Collagen synthesis, oxidative stress reduction
- 1–10 μM in vitro (in vivo dosing extrapolated)
- Daily or intermittent
- Enhanced fibroblast collagen production; reduced inflammation markers (Biomed Pharmacother)
- Complementary to BPC-157/TB-500; addresses oxidative component of chronic tendinopathy