Understand the source comparison
Best Glow Stack Dosage Youthful Skin 2026: Protocol Comparison
GHK-Cu (copper peptide) 1–2mg per dose, 2–3× weekly Subcutaneous injection Phase 3 trials show 70% increase in fibroblast collagen production Gold standard for matrix remodelling. Requires sterile technique and proper reconstitution Hydrolysed Collagen Peptide
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHK-Cu (copper peptide)
- 1–2mg per dose, 2–3× weekly
- Subcutaneous injection
- Phase 3 trials show 70% increase in fibroblast collagen production
- Gold standard for matrix remodelling. Requires sterile technique and proper reconstitution
- Hydrolysed Collagen Peptides
- 2.5–5g daily
- Oral, fasted state
- RCT data: 9% dermal density increase at 12 weeks
- Only effective at <3,000 Dalton molecular weight. Verify hydrolysis on product CoA
- Matrixyl 3000
- 3–8% concentration, twice daily
- Topical application
- Clinical trials: 45% wrinkle depth reduction at 60 days
- Concentration matters. Below 3% shows no statistical benefit vs vehicle
- Copper Peptides (topical)
- 0.05–0.1% copper concentration
- Topical serum
- Observational studies show improved skin texture
- Less bioavailable than injectable GHK-Cu but suitable for daily maintenance
- Palmitoyl Oligopeptide
- 2–4% concentration
- Topical cream or serum
- Limited RCT data, moderate effect size
- Weaker evidence than Matrixyl. Consider as adjunct, not primary
- Acetyl Hexapeptide-8 (Argireline)
- 5–10% concentration
- Small trials show temporary wrinkle smoothing
- Mechanism is muscle relaxation, not collagen synthesis. Different pathway