Understand the source comparison
Adamax Biomarkers: Assay Comparison
Mitochondrial-Derived Peptides (MOTS-c, Humanin) Mitochondrial transcriptional activity, proteostatic capacity 2–4 weeks post-intervention Degrades 15–25% in 30 min at room temp without protease inhibitors Gold standard for early mitochondrial dysfunction. Det
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- Mitochondrial-Derived Peptides (MOTS-c, Humanin)
- Mitochondrial transcriptional activity, proteostatic capacity
- 2–4 weeks post-intervention
- Degrades 15–25% in 30 min at room temp without protease inhibitors
- Gold standard for early mitochondrial dysfunction. Detects changes months before HbA1c or lipid shifts
- Oxidative Damage Markers (8-OHdG, MDA)
- DNA oxidation, lipid peroxidation
- 1–2 weeks post-oxidative stress
- Stable if frozen immediately; atmospheric exposure generates false positives
- Sensitive but artifact-prone. Requires nitrogen-purged tubes to avoid confounding
- Inflammatory Cytokine Fragments (IL-6, TNF-α)
- Inflammasome activation, systemic inflammation
- 3–7 days post-inflammatory trigger
- Relatively stable; minimal degradation at −80°C
- Useful for acute inflammation but less specific for chronic metabolic stress
- Traditional Metabolic Panel (HbA1c, Lipids)
- Glycemic control, lipid metabolism
- 8–12 weeks (chronic exposure)
- Highly stable; standard clinical processing
- Endpoint measures. Captures dysfunction after months of accumulation