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5-Amino-1MQ Energy Protocol: Dosing and Duration Comparison
2-week acute protocol 50mg/day Measurable within 10–14 days via indirect calorimetry Increased ATP/ADP ratio, reduced lactate accumulation during exertion Short-term metabolic reset; often used before extended fasting or caloric restriction phases 8-week susta
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- 2-week acute protocol
- 50mg/day
- Measurable within 10–14 days via indirect calorimetry
- Increased ATP/ADP ratio, reduced lactate accumulation during exertion
- Short-term metabolic reset; often used before extended fasting or caloric restriction phases
- 8-week sustained protocol
- 50–75mg/day
- Peak effect at 4–6 weeks; NAD+ stabilises at 30–40% above baseline
- Improved oxygen consumption (VO2), enhanced fatty acid oxidation, reduced inflammatory cytokines
- Standard research duration; allows full mitochondrial adaptation and metabolic remodelling
- Cyclical protocol (4 weeks on, 2 weeks off)
- 75mg/day during active phase
- NAD+ declines 15–20% during off-cycle but remains above pre-intervention baseline
- Sustained improvement in resting metabolic rate; prevents NNMT receptor downregulation
- Mimics natural enzymatic cycling; reduces tolerance risk and extends long-term viability