Watch our Short Video on JPT's Peptide Libraries!

Determining the events that lead to autoimmunity requires reagents to specifically detect the autoimmune rather than the normal physiological interactions, an ideal tool to address this is peptide libraries. Peptide libraries containing all human autoantigens, such as myelin basic protein, insulin or joint-specific collagens, are synthesized in all possible posttranslationally modified forms known to be present in the disease state, including citrullination, deamidation, and oxidation. Human T-cell clones from the periphery of patients and controls are then screened with these libraries in either tolerogenic or proinflammatory cytokine environments in order to identify which modified peptides contain cryptic epitopes that escaped central deletion and lead to tissue-specific inflammation. Alanine-scanning and position-substitution variants are used to more precisely determine the minimal amino acid motifs necessary for the peptide to become an encephalitogenic or arthritogenic peptide. In addition to mechanistic study, the peptide libraries are used to discover the tolerogenic peptides themselves; through structure–activity relationships, analogues that can anergize autoreactive T cells or induce antigen-specific regulatory T cells can be identified.

Published on 17/04/2026 The transition from discovery research to clinical development is one of the most critical phases in medicinal research. Data generated in early screening and target discovery must now be translated into robust, reproducible, and regulatory-compliant tools suitable for clinical studies. This requires peptide libraries to be produced under stringent production conditions. JPT’s Trial Grade and Premium Grade peptide libraries support: Immune monitoring and response profiling Biomarker validation Patient stratification Assay standardization across trial sites In this final newsletter, we highlight how JPT supports clinical research through Trial Grade and Premium Grade peptides. Trial Track Peptide Libraries As the name implies, PepTrack Trial Track is tailored to support peptide-based applications in clinical trials, ensuring that peptides used in clinical assays meet the quality and reproducibility requirements needed for reliable clinical data generation. Applications: Antigen-specific stimulation of T-cells for immune monitoring or immunotherapy in clinical trials Quality: For even higher quality, please check out our Clinical Peptides & Pools! Purity: > 80%, 90%, 95% or 97% guaranteed for each peptide Capping: Truncated peptides are capped after each synthesis step. This eliminates the major source of false positive T-cell responses, deletion peptides. QC /QA: LC-MS for each peptide Peptide Length: 15 aa Amount per Peptide: 1-4mg or 5-10mg Delivery Format: Freeze-dried in 96 tube racks Delivery Time: 4-5 weeks Minimum Order: 24 peptides But wait, there is more! Premium Grade PepMix™ – Bridging Research and Clinical Use Did you know we also offer Premium Grade peptide control pools? At the interface between discovery and clinical research, Premium Grade PepMix™ provides a highly standardized solution for immune monitoring and translational studies. Compared to regular control pools, Premium Grade PepMix™ offers: High purity (>90%) and consistency (validated pooling methods) Optimized performance in immunological assays Recurrent Performance testing Cytotox, endoxin, steriliy testing Updated CoA 637,50after each test Controlled synthesis processes Additional capping step to each peptide synthesis step to prevent de novo epitope formation High batch-to-batch consistency Comprehensive analytical documentation Customized plate and vial formats Support for longitudinal and multi-center studies