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Tula Skincare Eye Recharge + Replenish Pro-Ferm™ Overnight Eye Cream with Bakuchiol and Peptides Versus Skinfix Barrier+ Triple Lipid & Collagen Brightening Eye Treatment

Tula Skincare Eye Recharge + Replenish Pro-Ferm™ Overnight Eye Cream with Bakuchiol and Peptides Versus Skinfix Barrier+ Triple Lipid & Collagen Brightening Eye Treatment This anti-aging eye moisturizer is formulated around Bakuchiol and Retinal to soften the

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Tula Skincare Eye Recharge + Replenish Pro-Ferm™ Overnight Eye Cream with Bakuchiol and Peptides Versus Skinfix Barrier+ Triple Lipid & Collagen Brightening Eye Treatment

This anti-aging eye moisturizer is formulated around Bakuchiol and Retinal to soften the look of wrinkles.

This barrier-repair eye moisturizer is formulated around Niacinamide and Squalane to strengthen the skin barrier and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Butyrospermum Parkii Butter

Glycerin

Squalane

Isopentyldiol

Myristyl Myristate

Butylene Glycol

1,2-Hexanediol

Pentaerythrityl Tetraisostearate

Lactococcus Ferment Lysate

Arachidyl Alcohol

Cetearyl Olivate

Glyceryl Stearate

Oenothera Biennis Oil

Pseudozyma Epicola/Camellia Sinensis Seed Oil Ferment Extract Filtrate

Bakuchiol

Retinal

Lactobacillus

Lactobacillus Ferment

Haematococcus Pluvialis Extract

Beta Vulgaris Root Extract

Curcuma Longa Root Extract

Rosmarinus Officinalis Leaf Extract

Palmitoyl Tetrapeptide-7

Inulin

Alpha-Glucan Oligosaccharide

Ceramide NP

Lactic Acid

Ceramide AP

Ceramide As

Ceramide Ns

Chrysin

Ceramide EOP

Chamomilla Recutita Flower Extract

Cholesterol

Squalene

Behenyl Alcohol

Sorbitan Olivate

Sodium Polyacryloyldimethyl Taurate

Arachidyl Glucoside

Sodium Polyacrylate Starch

Sodium Polyglutamate

Phosphatidylcholine

Pentylene Glycol

Sodium Dilauramidoglutamide Lysine

2,3-Butanediol

Polymnia Sonchifolia Root Juice

Hydrogenated Lecithin

Maltodextrin

Sodium Benzoate

Citric Acid

Tocopherol

Phytic Acid

Potassium Sorbate

Sodium Chloride

Beta-Sitosterol

Calcium Alginate

Caprylyl Glycol

Lecithin

Propanediol

Sodium Hydroxide

Xanthan Gum

Water, Butyrospermum Parkii Butter, Glycerin, Squalane, Isopentyldiol, Myristyl Myristate, Butylene Glycol, 1,2-Hexanediol, Pentaerythrityl Tetraisostearate, Lactococcus Ferment Lysate, Arachidyl Alcohol, Cetearyl Olivate, Glyceryl Stearate, Oenothera Biennis Oil, Pseudozyma Epicola/Camellia Sinensis Seed Oil Ferment Extract Filtrate, Bakuchiol, Retinal, Lactobacillus, Lactobacillus Ferment, Haematococcus Pluvialis Extract, Beta Vulgaris Root Extract, Curcuma Longa Root Extract, Rosmarinus Officinalis Leaf Extract, Palmitoyl Tetrapeptide-7, Inulin, Alpha-Glucan Oligosaccharide, Ceramide NP, Lactic Acid, Ceramide AP, Ceramide As, Ceramide Ns, Chrysin, Ceramide EOP, Chamomilla Recutita Flower Extract, Cholesterol, Squalene, Behenyl Alcohol, Sorbitan Olivate, Sodium Polyacryloyldimethyl Taurate, Arachidyl Glucoside, Sodium Polyacrylate Starch, Sodium Polyglutamate, Phosphatidylcholine, Pentylene Glycol, Sodium Dilauramidoglutamide Lysine, 2,3-Butanediol, Polymnia Sonchifolia Root Juice, Hydrogenated Lecithin, Maltodextrin, Sodium Benzoate, Citric Acid, Tocopherol, Phytic Acid, Potassium Sorbate, Sodium Chloride, Beta-Sitosterol, Calcium Alginate, Caprylyl Glycol, Lecithin, Propanediol, Sodium Hydroxide, Xanthan Gum

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Niacinamide

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Collagen Amino Acids

Caffeine

Macadamia Integrifolia Seed Oil

Asparagopsis Armata Extract

Hydrogenated Starch Hydrolysate

Phytosteryl Macadamiate

Acetyl Glucosamine

Acetyl Glutamine

Phospholipids

Leuconostoc/Radish Root Ferment Filtrate

Polyglutamic Acid

Phytosterols

Ascophyllum Nodosum Extract

Bacillus/Soybean Ferment Extract

Oligopeptide-3

Oligopeptide-2

Oligopeptide-1

Hexapeptide-11

Tocopheryl Acetate

Sodium Hyaluronate

Folic Acid

Amylopectin

Phytosphingosine

Lithothamnion Calcareum Extract

Myrica Cerifera Fruit Extract

Hydroxyacetophenone

Prunus Lannesiana Flower Extract

Akebia Quinata Stem Extract

Saccharomyces Lysate

Lactobacillus Ferment Lysate

Tripeptide-1

Polysorbate 60

Ethylhexylglycerin

Hexylene Glycol

Sodium Lauroyl Lactylate

Sorbitan Isostearate

Trisodium Ethylenediamine Disuccinate

Carbomer

Dextran

Phenoxyethanol

Water, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Propanediol, Niacinamide, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Collagen Amino Acids, Squalane, Caffeine, Squalene, Macadamia Integrifolia Seed Oil, Asparagopsis Armata Extract, Hydrogenated Starch Hydrolysate, Phytosteryl Macadamiate, Acetyl Glucosamine, Acetyl Glutamine, Lecithin, Phospholipids, Leuconostoc/Radish Root Ferment Filtrate, Polyglutamic Acid, Phytosterols, Ascophyllum Nodosum Extract, Ceramide NP, Bacillus/Soybean Ferment Extract, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Tocopheryl Acetate, Sodium Hyaluronate, Folic Acid, Amylopectin, Tocopherol, Phytosphingosine, Ceramide AP, Cholesterol, Lithothamnion Calcareum Extract, Lactic Acid, Myrica Cerifera Fruit Extract, Hydroxyacetophenone, Prunus Lannesiana Flower Extract, Akebia Quinata Stem Extract, Saccharomyces Lysate, Lactobacillus Ferment Lysate, Ceramide EOP, Tripeptide-1, Caprylyl Glycol, Polysorbate 60, Glycerin, Ethylhexylglycerin, Hexylene Glycol, Sodium Lauroyl Lactylate, Sorbitan Isostearate, Trisodium Ethylenediamine Disuccinate, Butylene Glycol, Pentylene Glycol, Xanthan Gum, Carbomer, Sodium Benzoate, Potassium Sorbate, 1,2-Hexanediol, Dextran, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.

You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.

The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.

Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.

Ceramide EOP is formally known as Ceramide 1.

It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).

Low levels of Ceramide EOP have been found in people with eczema and psoriasis.

Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.

In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.

You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Lactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.

Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.

Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.

Like glycolic acid, it can:

Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.

Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.

To get results, choose products with a pH between 3-4.

Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.

Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.

When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.

Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.

Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.

Read more about some other popular AHA's here:

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Squalene is one of the main components of skin surface lipids. It is naturally found in our skin and makes up about 13% of sebum.

Topically, it is an emollient and skin conditioning agent.

Research highlights its role in antioxidant activity, anti-inflammatory effects, skin barrier protection, and wound healing support.

In vivo research has shown that transepidermal water loss (TEWL) caused by irritant exposure can be reverse with squalene supplementation (pointing to barrier recovery support).

Its antioxidant activity is backed by ex vivo and cell-based evidence showing it can scavenge free radicals but large-scale human clinical trials isolating this effect remain limited.

One study found squalene regulated proinflammatory behavior in ways relevant to wound healing, and in vitro fibroblast studies also shows it stimulates cell migration which is a key step in skin repair.

There's just one nuance to know about this ingredient:

Squalene is particularly vulnerable to oxidation; it breaks down from UV exposure 10x faster than the other lipids on your skin's surface. The byproducts of that breakdown can clog pores and trigger inflammation, potentially worsening acne.

This is why squalene is often hydrogenated into its stable counterpart: squalane (with an "a"). Most great formulations will have alreadu kept this in mind.

Squalene has shown no significant clinical evidence of sensitization and is a great hydrating ingredient.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

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Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

Research context

Read sources and limitations before applying a claim.

Case Studies and Research

Numerous case studies and research have demonstrated the effectiveness of functional medicine in managing chronic diseases. For example, a study published in the Journal of Clinical Rheumatology found that functional medicine approaches can significantly improve symptoms and quality of life in patients with rheumatoid arthritis. Another study published in the Journal of Alternative and Complementary Medicine found that functional medicine interventions can reduce blood pressure and improve cardiovascular health in patients with hypertension. These studies highlight the importance of functional medicine in addressing the root causes of chronic diseases and promoting optimal health and well-being.

Source: yoodirecthealth.com ↗
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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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