Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Tatcha Indigo Overnight Repair Versus Biossance Squalane + Ectoin Overnight Rescue Deep Repair Night Cream

Tatcha Indigo Overnight Repair Versus Biossance Squalane + Ectoin Overnight Rescue Deep Repair Night Cream This barrier-repair night moisturizer is formulated around Camellia Sinensis Leaf and Ceramide Ng to strengthen the skin barrier and calm redness. This b

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Tatcha Indigo Overnight Repair Versus Biossance Squalane + Ectoin Overnight Rescue Deep Repair Night Cream

This barrier-repair night moisturizer is formulated around Camellia Sinensis Leaf and Ceramide Ng to strengthen the skin barrier and calm redness.

This barrier-repair night moisturizer is formulated around Squalane and Ectoin to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Diglycerin

Camellia Sinensis Leaf

Glycerin

Diphenylsiloxy Phenyl Trimethicone

Neopentyl Glycol Diethylhexanoate

Butylene Glycol

Diisostearyl Malate

PEG-10 Dimethicone

Propanediol

Disteardimonium Hectorite

Ophiopogon Japonicus Root Extract

Indigofera Tinctoria Leaf Extract

Ceramide Ng

Palmitic Acid

Linoleic Acid

Sodium Hyaluronate

Polygonum Tinctorium Leaf/Stem Extract

Cetyl Alcohol

Sucrose Stearate

Sucrose Palmitate

Maltodextrin

Sargassum Vulgare Extract

Saccharomyces Ferment Filtrate

Hydrolyzed Lagenaria Siceraria Fruit Juice

Salvia Miltiorrhiza Root Extract

Tocopherol

Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone

Magnesium Sulfate

Hydrogenated Lecithin

Phytosterols

Ethylhexylglycerin

Phenoxyethanol

Mica

CI 77891

Water, Dimethicone, Diglycerin, Camellia Sinensis Leaf, Glycerin, Diphenylsiloxy Phenyl Trimethicone, Neopentyl Glycol Diethylhexanoate, Butylene Glycol, Diisostearyl Malate, PEG-10 Dimethicone, Propanediol, Disteardimonium Hectorite, Ophiopogon Japonicus Root Extract, Indigofera Tinctoria Leaf Extract, Ceramide Ng, Palmitic Acid, Linoleic Acid, Sodium Hyaluronate, Polygonum Tinctorium Leaf/Stem Extract, Cetyl Alcohol, Sucrose Stearate, Sucrose Palmitate, Maltodextrin, Sargassum Vulgare Extract, Saccharomyces Ferment Filtrate, Hydrolyzed Lagenaria Siceraria Fruit Juice, Salvia Miltiorrhiza Root Extract, Tocopherol, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Magnesium Sulfate, Hydrogenated Lecithin, Phytosterols, Ethylhexylglycerin, Phenoxyethanol, Mica, CI 77891

Squalane

Shorea Stenoptera Seed Butter

Caprylic/Capric Triglyceride

C12-16 Alcohols

Sodium Acrylates Copolymer

Ectoin

Jojoba Esters

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Lecithin

Magnesium Chloride

Sodium Gluconate

Caprylyl Glycol

Acetyl Hexapeptide-8

Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic/Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Palmitic Acid, Phenoxyethanol, Hydrogenated Lecithin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Magnesium Chloride, Ethylhexylglycerin, Sodium Gluconate, Caprylyl Glycol, Acetyl Hexapeptide-8

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.

In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.

Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.

The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.

The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.

In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →