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Summer Fridays Cloud Dew Oil-Free Gel Cream Moisturizer Versus Dear, Klairs Rich Moist Soothing Cream

Summer Fridays Cloud Dew Oil-Free Gel Cream Moisturizer Versus Dear, Klairs Rich Moist Soothing Cream This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Hydrolyzed Sodium Hyaluronate to strengthen the skin barrier and hydrate skin. Thi

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Summer Fridays Cloud Dew Oil-Free Gel Cream Moisturizer Versus Dear, Klairs Rich Moist Soothing Cream

This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Hydrolyzed Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.

This calming moisturizer is formulated around Butyrospermum Parkii Butter and Simmondsia Chinensis Seed Oil to calm redness and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Propanediol

Dicaprylyl Carbonate

Glycerin

Pentylene Glycol

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Glycine

Serine

Glutamic Acid

Aspartic Acid

Leucine

Alanine

Lysine

Arginine

Tyrosine

Phenylalanine

Proline

Threonine

Valine

Isoleucine

Histidine

Ascorbic Acid

Saccharide Isomerate

Haematococcus Pluvialis Extract

Ceramide NP

Tocopheryl Acetate

Tocopherol

Hexapeptide-11

Palmitoyl Tripeptide-1

Ananas Sativus Fruit Extract

Saccharomyces/Magnesium Ferment

Saccharomyces/Copper Ferment

Saccharomyces/Silicon Ferment

Butylene Glycol

Glyceryl Acrylate/Acrylic Acid Copolymer

Glyceryl Caprylate

Sucrose Stearate

Lecithin

Polyglyceryl-10 Laurate

Xanthan Gum

Cetearyl Olivate

Sorbitan Olivate

Sodium Citrate

Carbomer

Citric Acid

Cetearyl Alcohol

Sodium Hydroxide

Lactobacillus Ferment

Leuconostoc/Radish Root Ferment Filtrate

Hydroxyacetophenone

CI 77491

Water, Propanediol, Dicaprylyl Carbonate, Glycerin, Pentylene Glycol, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Glycine, Serine, Glutamic Acid, Aspartic Acid, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Threonine, Valine, Isoleucine, Histidine, Ascorbic Acid, Saccharide Isomerate, Haematococcus Pluvialis Extract, Ceramide NP, Tocopheryl Acetate, Tocopherol, Hexapeptide-11, Palmitoyl Tripeptide-1, Ananas Sativus Fruit Extract, Saccharomyces/Magnesium Ferment, Saccharomyces/Copper Ferment, Saccharomyces/Silicon Ferment, Butylene Glycol, Glyceryl Acrylate/Acrylic Acid Copolymer, Glyceryl Caprylate, Sucrose Stearate, Lecithin, Polyglyceryl-10 Laurate, Xanthan Gum, Cetearyl Olivate, Sorbitan Olivate, Sodium Citrate, Carbomer, Citric Acid, Cetearyl Alcohol, Sodium Hydroxide, Lactobacillus Ferment, Leuconostoc/Radish Root Ferment Filtrate, Hydroxyacetophenone, CI 77491

Caprylic/Capric Triglyceride

Cyclopentasiloxane

Cetyl Alcohol

Glyceryl Stearate

Cetyl Ethylhexanoate

Butyrospermum Parkii Butter

Simmondsia Chinensis Seed Oil

Stearic Acid

Sorbitan Sesquioleate

Microcrystalline Wax

Betaine

Sorbitan Stearate

PEG-100 Stearate

Dimethicone

Chlorphenesin

Paeonia Suffruticosa Root Extract

Illicium Verum Fruit Extract

Nelumbium Speciosum Flower Extract

Citrus Paradisi Fruit Extract

Scutellaria Baicalensis Root Extract

Beta-Glucan

Hydrogenated Lecithin

Portulaca Oleracea Extract

1,2-Hexanediol

Centella Asiatica Extract

Aloe Barbadensis Leaf Extract

Althaea Rosea Flower Extract

Disodium EDTA

Polyquaternium-51

Apium Graveolens Extract

Brassica Rapa Leaf Extract

Oryza Sativa Bran Extract

Brassica Oleracea Capitata Leaf Extract

Disodium Adenosine Triphosphate

Daucus Carota Sativa Root Extract

Brassica Oleracea Italica Extract

Solanum Lycopersicum Fruit/Leaf/Stem Extract

Lysine Hcl

Sodium Ascorbyl Phosphate

Acetyl Methionine

Theanine

Palmitic Acid

Arachidic Acid

Oleic Acid

Algin

Carica Papaya Fruit Extract

Natto Gum

Citrus Limon Peel Oil

Lavandula Angustifolia Oil

Citrus Aurantium Dulcis Peel Oil

Pelargonium Graveolens Flower Oil

Cananga Odorata Flower Oil

Eucalyptus Globulus Leaf Oil

Water, Glycerin, Caprylic/Capric Triglyceride, Cyclopentasiloxane, Cetyl Alcohol, Glyceryl Stearate, Cetyl Ethylhexanoate, Butyrospermum Parkii Butter, Simmondsia Chinensis Seed Oil, Stearic Acid, Butylene Glycol, Sorbitan Sesquioleate, Microcrystalline Wax, Betaine, Sorbitan Stearate, PEG-100 Stearate, Dimethicone, Arginine, Carbomer, Chlorphenesin, Tocopheryl Acetate, Paeonia Suffruticosa Root Extract, Illicium Verum Fruit Extract, Nelumbium Speciosum Flower Extract, Citrus Paradisi Fruit Extract, Scutellaria Baicalensis Root Extract, Citric Acid, Beta-Glucan, Hydrogenated Lecithin, Portulaca Oleracea Extract, 1,2-Hexanediol, Centella Asiatica Extract, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Sodium Hyaluronate, Ceramide NP, Disodium EDTA, Polyquaternium-51, Apium Graveolens Extract, Brassica Rapa Leaf Extract, Oryza Sativa Bran Extract, Brassica Oleracea Capitata Leaf Extract, Disodium Adenosine Triphosphate, Daucus Carota Sativa Root Extract, Brassica Oleracea Italica Extract, Solanum Lycopersicum Fruit/Leaf/Stem Extract, Lysine Hcl, Sodium Ascorbyl Phosphate, Acetyl Methionine, Theanine, Proline, Palmitic Acid, Arachidic Acid, Oleic Acid, Sodium Hydroxide, Algin, Carica Papaya Fruit Extract, Natto Gum, Citrus Limon Peel Oil, Lavandula Angustifolia Oil, Citrus Aurantium Dulcis Peel Oil, Pelargonium Graveolens Flower Oil, Cananga Odorata Flower Oil, Eucalyptus Globulus Leaf Oil

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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