State of Peptide Therapy in the US — 2026 Data Report

For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

State of Peptide Therapy in the US — 2026 Data Report

An analysis of 4,733 active peptide therapy clinics across the United States: which peptides are most widely prescribed, where clinics are concentrated, and how the GLP-1 boom has reshaped the landscape.

Key Findings

4,733

Active clinics indexed

across all 50 US states

48%

of clinics offer semaglutide

the most widely prescribed peptide

peptides tracked

with 100+ prescribing clinics each

FL + TX

top 2 states by clinic count

652 and 633 clinics respectively

Most Widely Prescribed Peptides by US Clinics (2026)

Ranked by number of active clinics in our database that offer each peptide. Each clinic is counted once per peptide regardless of the number of locations.

Semaglutide

2,285

48.3%

Tirzepatide

1,745

36.9%

NAD+

977

20.6%

Sermorelin

777

16.4%

PT-141

499

10.5%

Liraglutide

491

10.4%

BPC-157

308

6.5%

Tesamorelin

258

5.5%

GHK-Cu (Copper Peptide)

203

4.3%

Ipamorelin

248

5.2%

CJC-1295

193

4.1%

TB-500

183

3.9%

AOD-9604

150

3.2%

Retatrutide

144

3.0%

MOTS-c

113

2.4%

Data as of March 5, 2026. Source: MyPeptideMatch.com clinic database.See methodology.

The GLP-1 Boom: Semaglutide and Tirzepatide Dominate

GLP-1 receptor agonists now dominate peptide clinic offerings. Semaglutide is offered by 2,285 clinics (48% of all indexed clinics), making it by far the most common peptide in the US market — ahead of any traditional peptide therapy.

Tirzepatide ranks second at 1,745 clinics, reflecting rapid adoption following FDA approvals for type 2 diabetes (Mounjaro, 2022) and obesity (Zepbound, 2023). The compounding ban effective early 2025 has shifted many clinics back to brand-name prescriptions.

Among traditional peptides (non-GLP-1), NAD+ (977 clinics) and Sermorelin (777 clinics) remain the most broadly adopted, while sexual wellness peptide PT-141 appears at 499 clinics, second only to GLP-1 compounds and NAD+ among non-growth-hormone peptides.

Clinic Density by State

Florida and Texas together account for over 27% of all active indexed peptide therapy clinics in the US. Sun Belt states dominate, likely reflecting favorable regulatory environments, telehealth adoption, and population demographics.

Methodology

Data source: MyPeptideMatch.com maintains an independent database of US clinics that offer peptide therapy, hormone optimization, medical weight loss, and related services. Data is collected through a combination of publicly available information, clinic self-submission, and third-party verification.

Inclusion criteria: Clinics marked as "active" in the database as of the data pull date (March 5, 2026). A clinic is counted as offering a peptide if that peptide is listed in their services profile.

Limitations: This database represents a significant but not exhaustive sample of US clinics. Clinics not listed in the database are not counted. Peptide offering data relies on clinic self-reporting and may not capture every service each clinic provides.

Data freshness: This report reflects a snapshot as of March 5, 2026. The underlying database is updated continuously; the figures on this page refresh daily.

How to Cite This Report

MyPeptideMatch.com. (2026, March 5). State of Peptide Therapy in the US — 2026 Data Report. Retrieved from https://www.mypeptidematch.com/research/peptide-therapy-report-2026

This report is freely available for citation under CC BY 4.0. When citing, please link to this URL. For media inquiries, contact us at mypeptidematch.com/contact.

Find a peptide clinic near you

Search our directory of 4,733+ active US clinics by peptide, state, and treatment type.

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

Inflammation reduction versus fat reduction: which matters more?

This is the question that the Italian exenatide study highlighted so powerfully. Case 1 lost no weight but still experienced pain reduction and measurable changes in subcutaneous fat thickn…

Source: seekpeptides.com

comparison

Keto supplements versus GLP-1 medications: they are not the same thing

This distinction requires absolute clarity because confusion here can be dangerous. Exogenous ketone supplements, MCT oil products, and "keto pills" sold over the counter are NOT GLP-1 rece…

Source: seekpeptides.com

Research context

Read sources and limitations before applying a claim.

What the Research Says

While peptide therapy is still an emerging field, several high-quality studies support its potential: BPC-157: Animal studies and early human trials show accelerated healing of tendons, ligaments, and gut lining. Thymosin Alpha-1 (Tα1): Shown to enhance immune response in viral infections and improve vaccine efficacy. CJC-1295 & Ipamorelin: Commonly used for growth hormone stimulation, these peptides have been linked to increased lean muscle mass, reduced body fat, and improved sleep quality. PT-141 (Bremelanotide): FDA-approved for female sexual dysfunction, illustrating that peptides can pass rigorous regulatory hurdles. It's important to note that while some peptides have robust clinical data and regulatory approval, others are still under investigation. Always consult a qualified healthcare provider before starting any new therapy.

Source: ubiehealth.com ↗

Human Evidence Key

Extensive Multiple randomized controlled trials and/or established clinical use Moderate Multiple human studies with encouraging evidence, but not standard therapy Limited Small clinical studies or early-phase trials Very Limited / Minimal Predominantly animal, laboratory, or mechanistic research with little human evidence

Source: r2medicalclinic.com ↗

Practical and safety references

These excerpts are educational, not personalised medical instructions.

Dosage reference

Dosage

The recommended PT-141 dosage varies depending on the person. Many start with 0.5 milligrams (mg). Others require up to 2 mg for effects to work. It may involve some trial and error before you find a suitable amount. Bremelanotide usually kicks in around an hour after injecting it. Don’t use more than one injection per 24 hours.

Source: livvnatural.com ↗

Potential benefits

What are the benefits of Peptide Therapy?

With so many peptides out there, peptide therapies have a wide range of benefits, including weight loss, improved cognitive function, enhanced immune system, and many more. One specific peptide, known as Peptide CJC 1295, increases the production of a significant growth factor in our bodies. This peptide in treatment leads to fat loss, lean muscle growth, and better sleep. Other peptide formulations include Ipamorelin, which increases growth hormone production, increases lean muscle mass and stamina and decreases the refractory time between workouts. There is also frequent improvement in musculoskeletal issues resulting from tissue repair. Another peptide, known as Thymosin alpha-1 (TA1), improves the body’s ability to fight harmful viruses and bacteria. TA1 is the most common peptide used in peptide therapy, as many adults have opted to strengthen their immune systems through this treatment. Although less common in treatment than TA1, cerebrolysin is another peptide used more and more in peptide therapy because it enhances certain brain functions. When used in medicine, cerebrolysin has improved short and long-term memory, enhanced creativity, and increased motivation. While these are some of the most common forms of peptide treatment, there are many more types of peptide therapy out there, and their benefits include but are not limited to: enhanced sex drive, improved sexual performance, reduction in inflammation in the body, and decreased joint pain.

Source: charlestonhealthspan.com ↗

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →

State of Peptide Therapy in the US — 2026 Data Report

Key Findings

Most Widely Prescribed Peptides by US Clinics (2026)

The GLP-1 Boom: Semaglutide and Tirzepatide Dominate

Clinic Density by State

Methodology

How to Cite This Report

Find a peptide clinic near you

Related questions

Inflammation reduction versus fat reduction: which matters more?

Keto supplements versus GLP-1 medications: they are not the same thing

What the Research Says

Human Evidence Key

Dosage

What are the benefits of Peptide Therapy?

Peptide Therapy Guide Editorial Team

Elite Miami Peptides For Research — Peptide Therapy in Miami

Research Peptide Quality Standards

Adamax for Memory — Research Peptide Insights

Why Made in USA Matters for Research Peptide Quality