SLU-PP-332 Dosage Guide, Benefits & Side Effects

SLU-PP-332 Dosage Guide, Benefits & Side Effects

SLU-PP-332 activates ERR receptors to mimic aerobic training, boosting endurance and fat loss up to 70% in treadmill studies. See research.

Chemical Makeup

44

Amino Acids

SLU-PP-332

Glu

Position 1

His

Position 2

Tyr

Position 3

Asp

Position 4

Arg

Position 5

Pyl

Position 6

?

Position 7

Position 8

Asn

Position 9

Position 10

Ala

Position 11

Pro

Position 12

Position 13

Thr

Position 14

Position 15

Position 16

Leu

Position 17

Position 18

Position 19

Position 20

Position 21

Met

Position 22

Position 23

Position 24

Position 25

Position 26

Position 27

Position 28

Position 29

Position 30

Asx

Position 31

Position 32

Position 33

Glx

Position 34

Position 35

Position 36

Position 37

Position 38

Position 39

Position 40

Position 41

Ile

Position 42

Position 43

Position 44

As seen on

SLU-PP-332 Dosage Guide for Fat LossSLU-PP-332 Dosage Calculator

SLU-PP-332 is a lab-made compound (not technically a peptide) that helps boost mitochondrial function and endurance, and is used for fat loss. All the dosing data we have comes from mouse studies — there's no human safety data yet.

Vial size

20 mg

Bacteriostatic water

2 mL

Dosing

250–500 mcg

Frequency

5 days on / 2 days off

Cycle

8–12 weeks

Benefit

Fat Loss

SLU-PP-332 Dosage Guide for Performance / Lean MuscleSLU-PP-332 Dosage Calculator

SLU-PP-332 is a lab-made compound (not technically a peptide) that helps boost mitochondrial function and endurance, often used to support performance and lean muscle. All the dosing data we have comes from mouse studies — there's no human safety data yet.

1–1.5 mg

Performance / Lean Muscle

What is SLU-PP-332?

SLU-PP-332 is a lab-made compound (not a peptide) sometimes nicknamed 'exercise in a pill' because it turns on some of the same biological switches that regular exercise does, like helping muscle cells burn more fat and build more energy-producing power. So far it has only been tested in animals, largely because the current version doesn't absorb well when taken by mouth and clears from the body quickly. Researchers are studying it for obesity and metabolic health, with an improved successor compound already in development.

Longevity

Research targets include cellular aging, senescence, and long-term healthspan.

Metabolic

Research targets include glucose regulation, insulin sensitivity, and energy metabolism.

slu

Is SLU-PP-332 FDA approved?

SLU-PP-332 is not an FDA-approved drug. It is intended for research purposes only and is not approved for human consumption, diagnostic, or therapeutic use.

Research Use Only

SLU-PP-332 has not been evaluated by the FDA for safety or efficacy in humans.

No Clinical Oversight

Not manufactured under FDA-regulated quality or clinical standards.

Unregulated Sourcing

Purity, dosing, and sourcing are not verified through FDA testing or oversight.

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How Does SLU-PP-332 Work?

It directly switches on a family of receptors that control how many mitochondria a cell builds and how efficiently it burns fuel. Turning these receptors on essentially mimics, at the gene level, many of the same changes that regular endurance exercise produces in muscle and fat tissue.

Switches on a receptor family

Directly activates receptors that control mitochondria and fuel-burning.

Mimics exercise at the gene level

Turns on many of the same gene changes regular endurance training produces.

Boosts metabolism

Increases how efficiently muscle and fat tissue burn fuel.

SLU-PP-332 Targeted areas

How to reconstitute SLU-PP-332

The materials you'll need and step-by-step instructions for safely mixing SLU-PP-332 with bacteriostatic water.

Materials needed

Your SLU-PP-332 vial (lyophilized)

Alcohol swabs

Bacteriostatic sterile water

3 mL syringes (Luer Lock tip)

25G or 27G needles (Luer Lock). Other gauges may also be acceptable.

Sharps container (optional)

Remove the caps

Sanitize the rubber stoppers

Attach the needle

Draw the bac water

Pull back on the plunger to draw your desired volume of bacteriostatic water. If you overfill, just push the excess back in until you reach the right marker on the syringe.

Insert the needle into the SLU-PP-332 vial

With the bac water in your syringe, insert the needle into the SLU-PP-332 vial at a slight angle to avoid pressure buildup.

Release the water gently

Let the water run gently down the side of the vial. Don't inject it forcefully.

Swirl to dissolve

Avoid shaking. Gently swirl, flip, and roll the vial to dissolve the powder.

Check for full dissolution

Cap, dispose, and store

How to Store SLU-PP-332

The dry powder keeps in the freezer for at least four years. Dissolved in a lab solvent (DMSO), it needs a deep freezer for a few months or a regular freezer for just a month; once mixed into a water-based solution, refrigerate and use within about a month, avoiding repeated freezing and thawing.

Powder Storage

-20°C, stable for at least 4 years.

DMSO Solution Storage

-80°C for up to 6 months, or -20°C for 1 month.

Reconstituted Storage

In aqueous vehicle, 2–8°C for up to 28 days; avoid freeze-thaw cycles.

What Are the Benefits of SLU-PP-332?

What research says it may help with, and how it works in the body.

metabolic health

In obese mice, it significantly improved the body's ability to process blood sugar and lowered both fasting blood sugar and insulin levels.

Within 2 hours, it raises the amount of energy the body burns at rest by 25%, driven by increased burning of fat for fuel.

Reduced fatty liver disease, lowered fat levels stored in the liver, and improved the liver's ability to burn fat for energy.

Led to a 12% drop in body weight over 28 days without reducing appetite. Treated animals also gained less than 0.5 grams of fat, compared to about 5 grams in untreated animals.

exercise performance

In animal studies, it increased how long animals could run by 70% and how far they could run by 45%.

Increased the amount of a muscle fiber type built for endurance (type IIa), improving the muscles' ability to use oxygen for sustained energy.

antiaging

The first compound found to reverse age-related decline in the energy-producing parts of cells (mitochondria) in older, 21-month-old mice.

kidney protection

In elderly mice, it reversed the age-related rise in protein leaking into urine (a sign of kidney damage) and prevented the loss of specialized kidney filtering cells (podocytes).

cardiovascular

In heart failure studies, it improved the percentage of blood the heart pumps out with each beat (ejection fraction) and reduced stiff, scarred heart tissue (fibrosis).

What Are the Side Effects of SLU-PP-332?

Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds.

Who Should Avoid It

NOT FOR HUMAN USE - no approved human dose

No human clinical trials conducted

Potential interaction with diabetes medications

Stop Right Away If You Notice

Severe hypoglycemia (especially with diabetes medications)

Any cardiovascular symptoms (chest pain, palpitations, shortness of breath)

Signs of liver dysfunction (jaundice, dark urine, severe abdominal pain)

Kidney problems (reduced urination, swelling, severe back pain)

Severe headaches or neurological symptoms

Allergic reactions (rash, hives, difficulty breathing, swelling)

Milder Signs to Watch For

How Long Should a SLU-PP-332 Cycle Last?

This breaks down how long a typical SLU-PP-332 cycle runs and what research suggests happens at each stage. Research shows that staying on a peptide continuously, without a break, may make it less effective over time.

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again.

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Weight

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Fda Approved

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Cheat Sheets Featuring SLU-PP-332

See how SLU-PP-332 fits into a broader research stack with these free downloadable cheat sheets. Each one includes reference dose ranges, dosing frequency, and half-life for every peptide it covers. For research purposes only.

42 peptides

78 peptides

14 peptides

SLU-PP-332 Research References

It is a preclinical compound

SLU-PP-332 is a preclinical compound

Multiple mouse models, 50 mg/kg IP: 70% increase in running time, 45% increase in running distance, increased type IIa oxidative muscle fibers.

2023

21-month-old mice, 8-week treatment: Reversed age-related kidney decline, reduced albuminuria, prevented podocyte loss, restored mitochondrial architecture.

Diet-induced obese mice, 50 mg/kg IP twice daily, 28 days: 12% body weight loss, 25% fatty acid oxidation increase, improved glucose tolerance, reduced hepatic steatosis.

2024

Heart failure models, 6-week treatment: Improved ejection fraction, ameliorated cardiac fibrosis, improved survival, enhanced mitochondrial ultrastructure.

2021

Frequently Asked Questions About SLU-PP-332

Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.

What is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule compound (not a peptide in the classical amino-acid-chain sense, though it is commonly sold and discussed alongside peptides) developed by researchers at Saint Louis University. It is a pan-agonist of the estrogen-related receptor (ERR) family, activating ERRα, ERRβ, and ERRγ, with the strongest potency at ERRα. It is studied as a potential 'exercise mimetic' because it reproduces many of the gene-expression changes normally triggered by aerobic exercise.

How does SLU-PP-332 work?

SLU-PP-332 binds to and stabilizes the active conformation of ERR receptors, promoting recruitment of PGC-1α, a master coactivator of mitochondrial biogenesis. This drives transcription of genes involved in mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation in muscle, heart, and other metabolically active tissue. In animal studies this has translated into increased oxidative capacity and improved exercise endurance without requiring actual training.

What dosages are used in research settings?

There is no approved or standardized human dose because SLU-PP-332 has not completed human clinical trials. Preclinical (mouse) studies have used doses in the range of roughly 25-50 mg/kg administered intraperitoneally for up to 8 weeks. Some research-chemical vendors and online protocols suggest oral or injectable amounts in the low single-digit milligram range per day (e.g., 1.25-2.5 mg from a 5 mg vial), but these figures come from vendor/community sources rather than validated clinical dosing data and should not be treated as medical guidance.

What side effects have been reported?

Published rodent studies have not reported overt toxicity, liver enzyme abnormalities, or illness-related weight loss at the doses tested. Anecdotal reports from online research communities describe transient effects such as a mild rise in body temperature, increased sweating or hot flashes, fatigue after an initial energy increase, appetite changes, sleep disturbance, and elevated resting heart rate. These are uncontrolled, self-reported observations, not findings from controlled human trials, so the actual human side-effect profile is not well established.

Is SLU-PP-332 legal to buy and use?

SLU-PP-332 is not approved by the FDA, EMA, or any other major regulatory agency for any human use. It is sold by research chemical suppliers strictly labeled 'for laboratory/research use only, not for human consumption.' Because it has doping-relevant effects on metabolism, it has also been discussed as a compound of interest for anti-doping analytical characterization in sport. Buying it for personal use falls into a legal gray area in most jurisdictions and carries the same risks as any unregulated research chemical.

How should SLU-PP-332 be stored and reconstituted?

Community and vendor guidance suggests storing the lyophilized (powder) form in a freezer around -20°C, where it is reported to remain stable for extended periods. Once reconstituted (typically with bacteriostatic water), it is commonly recommended to keep the solution refrigerated at 2-8°C and use it within about 30 days, avoiding repeated freeze-thaw cycles. These are handling conventions from research-chemical suppliers rather than manufacturer-validated stability data, since no official human drug labeling exists.

What is the half-life of SLU-PP-332?

Estimates vary widely across sources, ranging from roughly 1.5-2 hours to 3-8 hours, based on preclinical pharmacokinetic data. There is no published, validated human half-life, so dosing-frequency claims built on these numbers should be treated as approximate at best.

Is SLU-PP-332 the same thing as exercise, and can it replace training?

No. SLU-PP-332 is studied because it reproduces some of the same gene-expression and mitochondrial changes seen with aerobic exercise training in animal models, which is why it is called an 'exercise mimetic.' It is not a proven substitute for physical activity in humans, has not been shown in human trials to improve endurance or metabolic health, and is not marketed or approved as a fitness or weight-loss product.