Educational guide
SkinCeuticals Triple Lipid Restore 2:4:2 Versus Biologique Recherche Crème Iso-Placenta Regenerating Face Cream
SkinCeuticals Triple Lipid Restore 2:4:2 Versus Biologique Recherche Crème Iso-Placenta Regenerating Face Cream This barrier-repair moisturizer is formulated around Cholesterol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles. Thi
This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.
SkinCeuticals Triple Lipid Restore 2:4:2 Versus Biologique Recherche Crème Iso-Placenta Regenerating Face Cream
This barrier-repair moisturizer is formulated around Cholesterol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.
This smoothing moisturizer is formulated around Niacinamide and Centella Asiatica Extract to refine skin texture and fade the look of dark spots.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Dimethicone
Hydrogenated Polyisobutene
Glycerin
Cholesterol
C12-15 Alkyl Benzoate
Ceramide NP
Helianthus Annuus Seed Oil Unsaponifiables
Bis-PEG-18 Methyl Ether Dimethyl Silane
Sodium Polyacrylate
PEG-10 Dimethicone
Nylon-12
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Dimethicone/PEG-10/15 Crosspolymer
Phenoxyethanol
Disteardimonium Hectorite
Hydroxyethylpiperazine Ethane Sulfonic Acid
Ammonium Polyacryloyldimethyl Taurate
Chlorphenesin
Caprylyl Glycol
PEG/PPG-18/18 Dimethicone
Propylene Carbonate
Disodium EDTA
Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer
Adenosine
Dipropylene Glycol
Lavandula Angustifolia Oil
Rosmarinus Officinalis Leaf Oil
T-Butyl Alcohol
Mentha Piperita Oil
Sodium Citrate
Linalool
Isobutane
Ceramide EOP
BHT
Tocopherol
Limonene
Water, Dimethicone, Hydrogenated Polyisobutene, Glycerin, Cholesterol, C12-15 Alkyl Benzoate, Ceramide NP, Helianthus Annuus Seed Oil Unsaponifiables, Bis-PEG-18 Methyl Ether Dimethyl Silane, Sodium Polyacrylate, PEG-10 Dimethicone, Nylon-12, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Phenoxyethanol, Disteardimonium Hectorite, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Chlorphenesin, Caprylyl Glycol, PEG/PPG-18/18 Dimethicone, Propylene Carbonate, Disodium EDTA, Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer, Adenosine, Dipropylene Glycol, Lavandula Angustifolia Oil, Rosmarinus Officinalis Leaf Oil, T-Butyl Alcohol, Mentha Piperita Oil, Sodium Citrate, Linalool, Isobutane, Ceramide EOP, BHT, Tocopherol, Limonene
Propylene Glycol
Dicaprylyl Carbonate
Sucrose Polystearate
C10-18 Triglycerides
Cetyl Alcohol
1,2-Hexanediol
Niacinamide
Passiflora Edulis Seed Oil
Polyamide-5
Betula Alba Bark Extract
Equisetum Arvense Extract
Hedera Helix Leaf/Stem Extract
Fucus Vesiculosus Extract
Centella Asiatica Extract
Glycine Soja Oil
Yeast Extract
Bacillus/Soybean Ferment Extract
Hexapeptide-11
Oligopeptide-1
Oligopeptide-2
Oligopeptide-3
Ascorbyl Glucoside
Acetyl Glutamine
Folic Acid
Sodium Hyaluronate
Lecithin
Sodium Stearoyl Glutamate
Butylene Glycol
Polyacrylate Crosspolymer-6
Water, Propylene Glycol, Dicaprylyl Carbonate, Glycerin, Sucrose Polystearate, C10-18 Triglycerides, Cetyl Alcohol, 1,2-Hexanediol, Niacinamide, Passiflora Edulis Seed Oil, Polyamide-5, Betula Alba Bark Extract, Equisetum Arvense Extract, Hedera Helix Leaf/Stem Extract, Fucus Vesiculosus Extract, Centella Asiatica Extract, Glycine Soja Oil, Yeast Extract, Bacillus/Soybean Ferment Extract, Hexapeptide-11, Oligopeptide-1, Oligopeptide-2, Oligopeptide-3, Ascorbyl Glucoside, Acetyl Glutamine, Folic Acid, Sodium Hyaluronate, Lecithin, Tocopherol, Sodium Stearoyl Glutamate, Butylene Glycol, Hydrogenated Polyisobutene, Polyacrylate Crosspolymer-6, T-Butyl Alcohol, Caprylyl Glycol
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hydrogenated Polyisobutene is a synthetic polymer. Polymers are compounds with high molecular weight. Hydrogenated Polyisobutene is an emollient and texture enhancer.
In one study, Hydrogenated Polyisobutene showed better skin hydration levels than Caprylic/Capric Triglyceride. As an emollient, it helps keep your skin soft and hydrated by trapping moisture in.
Hydrogenated Polyisobutene is often used as a mineral oil replacement.
T-Butyl Alcohol (aka tert-butanol) is a small, clear, camphor-smelling alcohol.
It has two main jobs:
On the safety side, it's well-studied and has a solid track record. Human repeat-insult patch testing showed no skin irritation or sensitization even at 100%.
Typical use levels are pretty tiny, usually less than 1%.
You might see some fear-mongering around this ingredient:
Studies in male rats showed kidney effects but that's because of a rat-specific protein that humans don't make. So this study isn't really relevant to humans.
Though it's not a typical fragrance like parfum, it does have a natural scent. That's why the official COSIng database lists it as 'perfuming' ingredient. It can be used to modify the scent of a formula.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!