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Sisley Paris Sisleÿa L'Intégral Anti-Age Eye & Lip Contour Cream Versus Estée Lauder Advanced Night Repair Eye Supercharged Complex

Sisley Paris Sisleÿa L'Intégral Anti-Age Eye & Lip Contour Cream Versus Estée Lauder Advanced Night Repair Eye Supercharged Complex This anti-aging eye moisturizer is formulated around Caffeine and Adenosine to soften the look of wrinkles. This barrier-repair

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Sisley Paris Sisleÿa L'Intégral Anti-Age Eye & Lip Contour Cream Versus Estée Lauder Advanced Night Repair Eye Supercharged Complex

This anti-aging eye moisturizer is formulated around Caffeine and Adenosine to soften the look of wrinkles.

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butyrospermum Parkii Butter

Glyceryl Myristate

Coco-Caprylate/Caprate

Hydrogenated Polyisobutene

Potassium Cetyl Phosphate

Citrus Aurantium Amara Flower Water

Rosa Centifolia Flower Water

Stearyl Alcohol

Cetearyl Alcohol

Isopropyl Palmitate

Panthenol

Tocopheryl Acetate

Caffeine

Cedrus Atlantica Bark Extract

Avena Sativa Kernel Extract

Hydrolyzed Soy Protein

Bisabolol

Saccharide Hydrolysate

Adenosine

Albizia Julibrissin Bark Extract

Punica Granatum Fruit Extract

Passiflora Edulis Fruit Extract

Hydrolyzed Yeast Protein

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Ceteareth-33

Butylene Glycol

Carbomer

Ethylhexylglycerin

Pentylene Glycol

Disodium EDTA

Sodium Hydroxide

Polysorbate 60

Sorbitan Isostearate

Citric Acid

Phenoxyethanol

Sodium Benzoate

Potassium Sorbate

BHT

Water, Glycerin, Butyrospermum Parkii Butter, Glyceryl Myristate, Coco-Caprylate/Caprate, Hydrogenated Polyisobutene, Potassium Cetyl Phosphate, Citrus Aurantium Amara Flower Water, Rosa Centifolia Flower Water, Stearyl Alcohol, Cetearyl Alcohol, Isopropyl Palmitate, Panthenol, Tocopheryl Acetate, Caffeine, Cedrus Atlantica Bark Extract, Avena Sativa Kernel Extract, Hydrolyzed Soy Protein, Bisabolol, Saccharide Hydrolysate, Adenosine, Albizia Julibrissin Bark Extract, Punica Granatum Fruit Extract, Passiflora Edulis Fruit Extract, Hydrolyzed Yeast Protein, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ceteareth-33, Butylene Glycol, Carbomer, Ethylhexylglycerin, Pentylene Glycol, Disodium EDTA, Sodium Hydroxide, Polysorbate 60, Sorbitan Isostearate, Citric Acid, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, BHT

Methyl Trimethicone

Bifida Ferment Lysate

Dimethicone

Dimethicone/Vinyl Dimethicone Crosspolymer

Propanediol

Sucrose

Petrolatum

Polysorbate 40

Trehalose

Algae Extract

Morus Bombycis Root Extract

Scutellaria Baicalensis Root Extract

Lactobacillus Ferment

Triticum Vulgare Germ Extract

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Betula Alba Bark Extract

Hydrolyzed Algin

Poria Cocos Sclerotium Extract

Jojoba Alcohol

Glycine Soja Seed Extract

Isopropyl Jojobate

Jojoba Esters

Isohexadecane

Faex Extract

Hydrogenated Lecithin

Hordeum Vulgare Extract

PEG/PPG-18/18 Dimethicone

Cholesterol

Anthemis Nobilis Flower Extract

Sodium Rna

Polysorbate 80

Caprylyl Glycol

Phytosphingosine

Squalane

Potassium Sulfate

Sodium Hyaluronate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tripeptide-32

Tromethamine

CI 77491

CI 77492

CI 77499

Methyl Trimethicone, Water, Bifida Ferment Lysate, Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Propanediol, Sucrose, Petrolatum, Polysorbate 40, Trehalose, Algae Extract, Morus Bombycis Root Extract, Scutellaria Baicalensis Root Extract, Lactobacillus Ferment, Triticum Vulgare Germ Extract, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Betula Alba Bark Extract, Hydrolyzed Algin, Poria Cocos Sclerotium Extract, Jojoba Alcohol, Ethylhexylglycerin, Glycine Soja Seed Extract, Isopropyl Jojobate, Jojoba Esters, Isohexadecane, Faex Extract, Hydrogenated Lecithin, Hordeum Vulgare Extract, PEG/PPG-18/18 Dimethicone, Cholesterol, Anthemis Nobilis Flower Extract, Tocopheryl Acetate, Sodium Rna, Caffeine, Polysorbate 80, Caprylyl Glycol, Phytosphingosine, Squalane, Potassium Sulfate, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tripeptide-32, Butylene Glycol, Tromethamine, Disodium EDTA, BHT, Phenoxyethanol, CI 77491, CI 77492, CI 77499

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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