Educational guide
Roles of calcitonin gene-related peptide in the skin, and ...
Skip to main content Skip to article View PDF Under a Creative Commons license Open access Highlights • CGRP can help to recruit immune cells through endothelium-dependent vasodilation. • CGRP plays an important role in the pathogenesis of neurogenic inflammat
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Skip to main contentSkip to article
Under a Creative Commons license
Open access
Highlights
- •
CGRP can help to recruit immune cells through endothelium-dependent vasodilation.
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CGRP plays an important role in the pathogenesis of neurogenic inflammation.
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Functions of many components in the immune system are influenced by CGRP.
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CGRP regulates various inflammatory processes in human skin by affecting different cell-types.
Abstract
Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin gene-related peptide (CGRP). CGRP has roles in regulating the function of components of the immune system including T cells, B cells, dendritic cells (DCs), endothelial cells (ECs), and mast cells (MCs).
Herein we discuss actions of CGRP in mediating inflammatory and vascular effects in various cutaneous models and disorders.
Keywords
Calcitonin gene-related peptide
CGRP
Skin immunity
Immunoregulation
Neurogenic inflammation
Cutaneous disorders
Therapeutic target
© 2021 The Authors. Published by Elsevier Inc.