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Repaglinide: Uses, Side Effects & Dosage | Healio

Topics Repaglinide Brand Names Prandin Generic Name repaglinide Phonetic Name (reh-PAGG-lin-ide) Clinical Uses Repaglinide is used alone or with other medications to control high blood sugar along with a proper diet and exercise program. It is used in people w

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Topics

Repaglinide

Brand Names

Prandin

Generic Name

repaglinide

Phonetic Name

(reh-PAGG-lin-ide)

Clinical Uses

Repaglinide is used alone or with other medications to control high blood sugar along with a proper diet and exercise program. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It works by stimulating the body to produce more insulin. Insulin is a natural substance that allows the body to properly use sugar from the diet.

Dosage and Administration

Preparations

  • 0.5 mg Brand(s): * Repaglinide Tablets
  • 1 mg Brand(s): * Repaglinide Tablets
  • 2 mg Brand(s): * Repaglinide Tablets

Administration Notes

Read the Patient Information leaflet if one is available from your pharmacist before you start using repaglinide and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth within 30 minutes before each meal as directed by your doctor, usually 2-4 times daily depending on the number of meals. Do not take a dose of medication if you are skipping that meal or if your blood sugar is low. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Use this medication regularly as directed by your doctor in order to get the most benefit from it. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended. Tell your doctor if your condition does not get better or if it gets worse (your blood sugar is too high or too low).

Missed Dose Instructions

If you miss a dose, skip that dose. Take your next dose with your next meal. Do not double the dose to catch up.

Label Warnings

Warning: Breastfeeding is not recommended while using this drug. Consult your doctor or pharmacist. Use this medication before a meal. Read label carefully for how many times to use each day. If you drink alcohol, discuss the safe use of alcohol while using this medication with your healthcare professional. This medication may cause low blood sugar if you skip meals or do not eat regularly. If you are pregnant or considering becoming pregnant you should discuss the use of this medication with your doctor or pharmacist.

Indications

  • type 2 diabetes mellitus

Repaglinide is used alone or with other medications to control high blood sugar along with a proper diet and exercise program. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It works by stimulating the body to produce more insulin. Insulin is a natural substance that allows the body to properly use sugar from the diet.

Contraindications

  • lactation
  • chronic kidney disease stage 3B (moderate) GFR 30-44 mL/min
  • chronic kidney disease stage 4 (severe) GFR 15-29 mL/min
  • chronic kidney disease stage 5 (failure) GFR<15 mL/min
  • alcohol intoxication
  • alcohol use disorder
  • debilitation
  • disease of liver
  • hypoglycemic disorder
  • invasive surgical procedure
  • kidney disease with likely reduction in glomerular filtration rate (GFR)
  • major traumatic injury
  • pituitary insufficiency
  • primary adrenocortical insufficiency
  • severe adrenal insufficiency
  • severe infection

Common Adverse Effects

  • Upper respiratory infection
  • Arthralgia
  • Back pain
  • Bronchitis
  • Constipation
  • Diarrhea
  • Dyspepsia
  • Headache disorder
  • Nausea
  • Rhinitis
  • Urinary tract infection
  • Vomiting
  • Alopecia
  • Paresthesia
  • Peripheral edema
  • Weight gain

Serious Adverse Effects

  • Pruritus of skin
  • Sinusitis
  • Skin rash
  • Tooth disorder
  • Abnormal hepatic function tests
  • Acute myocardial infarction
  • Acute pancreatitis
  • Anaphylaxis
  • Cardiac arrhythmia
  • Chest pain
  • Hemolytic anemia
  • Hepatitis
  • Hypertension
  • Hypoglycemic disorder
  • Jaundice
  • Leukopenia
  • Stevens-Johnson syndrome
  • Thrombocytopenic disorder

Elderly Precautions

Pregnancy Precautions

PrecautionSeverityNarrativeREPAGLINIDERequires a Risk/Benefit AssessmentInsufficient human data available. Animal data do not suggest developmental toxicity at doses less than 10 times the maximum recommended human dose.

Lactation Precautions

SeverityNarrativeAbsolute ContraindicationTHEORETICAL RISK OF INFANT HYPOGLYCEMIA

Pediatric Precautions

SeverityNarrativeManagement or Monitoring PrecautionSafety and efficacy not established in pediatrics. Not studied.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: NPH insulin. Other medications can affect the removal of repaglinide from your body, which may affect how repaglinide works. Examples include clopidogrel, gemfibrozil, trimethoprim, azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, among others. Many drugs can affect your blood sugar, making it harder to control. Examples include corticosteroids (such as prednisone), psychiatric medicines (such as olanzapine), fluoroquinolone antibiotics (such as ciprofloxacin), among others. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet. Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs. Check the labels on all your medicines (such as cough-and-cold products) carefully. Some products may contain sugar or alcohol and may affect your blood sugar. Ask your doctor or pharmacist about using these products safely. Other medications can affect the results of urine tests for sugar or ketones. Consult your doctor or pharmacist for more information.

Drug Interactions Table

Toxicology

Across 7 controlled trials, there were 6 serious adverse events of myocardial ischemia in patients treated with repaglinide and isophane (NPH) insulin from 2 studies, and 1 event in patients treated with insulin formulations alone from another study. Repaglinide is not indicated for use in combination with NPH insulin.

Storage Requirements

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by FDB, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution in professional health care settings.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment. See our full terms of use.

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking any drug or commencing or discontinuing any course of treatment.

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Related questions

01What should I know about repaglinide before using it?

Do not take repaglinide unless it has been prescribed to you by a healthcare provider. Take it as prescribed. Do not share repaglinide with other people, even if they have the same condition as you. It may harm them. Keep repaglinide out of the reach of children. Certain conditions that cause increased stress on your body, like fever, trauma (such as a car accident), infection, or surgery, can change the amount of diabetes medicines you need to take to control your diabetes. Talk to your healthcare provider if you have any of these conditions to decide if your medicine needs to be changed. Talk to your healthcare provider about how to prevent, recognize, and manage low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), and diabetes-related problems. Take repaglinide up to 30 minutes before each meal (up to 4 meals per day). You should skip your dose of repaglinide if you skip a meal. Repaglinide can affect your alertness or coordination, especially if your blood sugar drops too low. Do not drive or do other activities that require alertness or coordination until you know how repaglinide affects you.

Source: www.webmd.com ↗
02What is repaglinide, and how does it work (mechanism of action)?

Repaglinide is an oral medication for lowering blood sugar (glucose) in individuals with type 2 diabetes. It is in a class of drugs for treating diabetes type 2 called meglitinides that are chemically unlike other anti-diabetic medications. Nateglinide (Starlix), is another currently available meglitinide. Approximately 90% of patients with diabetes have type 2 or non-insulin dependent diabetes mellitus. Type 2 diabetes usually occurs in adulthood, and is associated with obesity, and a strong family history of diabetes. Glucose intolerance that causes diabetes type 2 is caused by reduced insulin secretion from the pancreas after meals and resistance of the body's cells to insulin's effect which is to stimulate the cells to remove glucose from the blood. This leads to high levels of glucose in the blood. Like sulfonylureas, for example, glyburide (Diabeta, Glynase), glipizide (Glucotrol, Glucotrol XL), glimepiride (Amaryl), tolbutamide and tolazamide, repaglinide stimulates cells in the pancreas to produce insulin. Glyburide may be more potent than repaglinide at increasing insulin release in persons with low or high blood glucose levels, whereas repaglinide may be more potent in persons with more moderate abnormalities of blood glucose levels. Repaglinide is different because it has a rapid onset of action and a short duration of action. When taken just prior to meals, it promotes the release of insulin that normally occurs with meals and is responsible for preventing blood glucose levels from becoming high. It has been shown to lower hemoglobin A1c (HbA1c) levels by 1.6% to 1.9%. (Hemoglobin A1c is a blood test which measures the effectiveness of a drug in controlling high blood glucose levels over prolonged periods of time; the lower the hemoglobin A1c, the better the control.) Repaglinide was approved by the FDA in 1997.

Source: www.medicinenet.com ↗
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