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References with PepTrack™ Peptide Libraries

JPT's PepTrack™ Peptide Libraries for Research References with PepTrack™ Peptide Libraries 2022 - 2025 Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse modelRenner et al.,

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JPT's PepTrack™ Peptide Libraries for Research

References with PepTrack™ Peptide Libraries

2022 - 2025

Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse modelRenner et al., Communications Medicine (2025) - PMID: 40217109

Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetesSamodova et al., Microbiome (2025) - PMID: 39794871Product used: Peptide Library of Top 7 peptide sequences from bacterial genera Corynebacterium and Neisseria

Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assaysSchwarzlose-Schwarck et al., BMC Infectious Diseases (2025) - PMID: 39920589 Product used: PepTrack Peptide Libraries, Custom PepMix etc.

STIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteinsStolle et al., EMBO Journal (2024) - PMID: 39192033

Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC InhibitorsKutil et al., ACS Omega (2024) - PMID: 31788622

Synthese und Untersuchung von peptidischen Substraten der HistondeacetylasenZessin, Dissertation (2024)

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrumIngels et al., Cell Reports Medicine (2024)

Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaquesVentura et al., NPJ Journals (2022)

Modulation der iNKT-(invariant natural killer T cells) Zell-Antwort durch das murine CytomegalovirusFranziska Blaum, Dissertation (2022)

Immune checkpoint blockade augments changes within oncolytic virus-induced cancer MHC-I peptidome, creating novel antitumor CD8 T cell reactivitiesKim et al., Molecular & Cellular Proteomics (2022)

Transcription factor EB sets the stage for fate decisions of antigen-primed B cells in the absence and presence of co-stimulationWienands et al., Research Square (2022)

2021

Proteogenomics of Non-Small Cell Lung Cancer Reveals Molecular Subtypes Associated With Specific Therapeutic Targets and Immune-Evasion MechanismsLethiö et al., Nature Cancer (2021) - PMID: 34870237

Long acting Capsid Inhibitor Protects Macaques from Repeat SHIV ChallengesVidal et al., Nature (2021) - PMID : 34875675

SARS-CoV-2 Mutations in MHC-I-Restricted Epitopes Evade CD8+ T Cell ResponsesBenedikt Agerer et. al., Science Immunology (2021) - PMID: 33664060

Durvalumab with Platinum-Pemetrexed for Unresectable Pleural Mesothelioma: Survival, Genomic and Immunologic Analyses From the Phase 2 PrE0505 TrialPatrick M Forde et al., Nature Medicine, (2021)

Transcriptional Programs of Neoantigen-Specific TIL in Anti-PD-1-Treated Lung CancersCaushi, J.X. et al., Nature, (2021)

CD4 T Cell Responses to Theileria parva in Immune Cattle Recognize a Diverse Set of Parasite Antigens Presented on the Surface of Infected LymphoblastsW. I. Morrison et al., J immunol., (2021)

Naturally Occurring Telomerase-Specific CD4 T-Cell Immunity in MelanomaCharlée Nardin et al., J Invest Dermatol., (2021)

Archive

Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb InfectionHelena Strand Clemmensen et al., Front Immunol (2020) - PMID: 33240275

Functional Evaluation and Genetic Evolution of Human T-cell Responses after Vaccination with a Conditionally Replication-Defective Cytomegalovirus VaccineKara S Cox et al., The Journal of Infectious Diseases (2020) - PMID: 33031517

Dominant Immune Response to HLA‐B57/B58 Molecules After Platelet TransfusionJustine Coombs et al., Transfusion (2020) - PMID: 33037638

Mapping Immunodominant Antibody Epitopes of AbrinRon Alcalay et al., Antibodies (2020) - PMID: 32349421

Identification of two HLA-A*0201 Immunogenic Epitopes of Lactate Dehydrogenase C (LDHC): Potential Novel Targets for Cancer ImmunotherapyRemy Thomas et al., Cancer Immunology, Immunotherapy (2020) - PMID: 31932876

Immunology of AgingSudhir Gupta et al., Frontiers in Immunology (2019) - PMID: n.a.

Identification of Naturally Processed Mumps Virus Epitopes by Mass Spectrometry: Confirmation of Multiple CD8+ T Cell Responses in Mumps PatientsJelle de Wit et al., The Journal of Infectious Diseases (2019) - PMID: 31560392

Mass Spectrometry Driven Exploration Reveals Nuancesof Neoepitope-Driven Tumor RejectionHakimeh Ebrahimi-Nik et al., Department of Immunology (2019) - PMID: 31219806

Rapalog Combined with CCR4 Antagonist Improves Anticancer Vaccines EfficacyBeziaud et al., International Journal of Cancer (2018) - PMID: 30183073

Molecular Recalibration of PD-1+ Antigen-Specific T Cells From Blood and LiverOtano et al., Molecular Therapy (2018) - PMID: n.a.

CD11c+ MHCIIlo GM-CSF-Bone Marrow-Derived Dendritic Cells Act as Antigen Donor Cells and as Antigen Presenting Cells in Neoepitope-Elicited Tumor Immunity Against a Mouse FibrosarcomaEbrahimi-Nik et al., Cancer Immunol Immunother. (2018) - PMID: 30030558

Generating Virus or Other Antigen-Specific T-Cells from a Naïve T-Cell PopulationBollard et al., US Patent App. 15/563,854 (2018) - PMID: n.a.

Characterization of the Immune Response Elicited by the Vaccinia Virus L3 Protein Delivered as Naked DNARamírez et al., Vaccine (2018) - PMID: 29525282

Human Papilloma Virus-Specific T Cells can be Generated from Naive T Cells for Use As An Immunotherapeutic Strategy for Immunocompromised PatientsMcCormack et al., Cytotherapy (2018) - PMID: 29331266

Detection of ABCB5-Tumour-Antigen-Specific CD8+ T Cells in Melanoma Patients and Implications for ImmunotherapyBorchers et al., Clin Exp Immunol. (2017) - PMID: 28940439

A Synthetic Human Cytomegalovirus pp65-IE1 Fusion Antigen Efficiently Induces and Expands Virus Specific T cellsEK Link et al., Vaccine. (2017) - PMID: 28818566

Sandwich Immunoassay for Bioactive Plasma AdrenomedullinJ Weber et al., J. of Applied Lab. Medicine (2017) - PMID: n.a.

Anti-HERV-K (HML-2) Capsid Antibody Responses in HIV Elite ControllersM de Mulder et al., Retrovirology. (2017) - PMID: 28830571

Immunogenicity Differences of a 15-Valent Pneumococcal Polysaccharide Conjugate Vaccine (PCV15) Based on Vaccine Dose, Route of Immunization and Mouse StrainCaro-Aguilar et al., Vaccine (2017) - PMID: 28087148

HCMV Specific CD4+ T Cells are Poly-Functional and can Respond to HCMV Infected Dendritic Cells In VitroJackson et al., Journal of Virology (2017) - PMID: 28053099

Environmental Factor and Inflammation-Driven Alteration of the Total Peripheral T-cell Compartment in Granulomatosis with PolyangiitisKerstein et al., Journal of Autoimmunity (2016) - PMID: 28040323

Array-in-Well Binding Assay for Multiparameter Screening of Phage Displayed AntibodiesPérez-Gamarra et al., Methods (2016) - PMID: 27956240

Identification of Theileria lestoquardi Antigens Recognized by CD8+ T CellsGoh et al., Plos One (2016) - PMID: 27611868

Identification of Epitopes Recognised by Mucosal CD4+ T-cell Populations from Cattle Experimentally Colonised with Escherichia Coli O157: H7Corbishley et al., Veterinary Research (2016) - PMID: 27590451

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral ChallengeMagini et al., PloS one (2016) - PMID: 27525409

Identification of a A Naturally Processed HLA-A*02:01-Restricted CTL Epitope From the Human Tumor-Associated Antigen Nectin-4Lopez et al., Cancer immunology, immunotherapy (2016) - PMID: 27514672

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection Against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn PigsSchnee et al., PLOS Negl Trop Dis (2016) - PMID: 27336830

Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell ResponsesHolgado et al., Viruses (2016) - PMID: 27223301

Peanut T-Cell Epitope Discovery: Ara h 1Ramesh et al., J Allergy Clin Immunol. (2016) - PMID: 26953158

Protein-Prime/Modified Vaccinia Virus Ankara Vector-boost Vaccination Overcomes Tolerance in High-antigenemic HBV-transgenic MiceBackes et al., Vaccine (2016) - PMID: 26776470

Identification of Theileria Lestoquardi Antigens Recognized by CD8.sup.+ T CellsShan Goh et al., PLoS ONE (2016) - PMID: 27611868

Effective Treatment with Intravenous Immunoglobulins Reduces Autoreactive T-cell Response in Patients with CIDPKlehmet et al., J. Neurol. Neurosurg. Psychiatry (2015) - PMID: 25074566

Thelper2 Response in Allergic Bronchopulmonary Aspergillosis Is Not driven by Specific Aspergillus AntigensJolink et al., Allergy (2015) - PMID: 26179335

IL-17/IL-10 Double-Producing T Cells: New Link Between Infections, Immunosuppression and Acute Myeloid LeukemiaMusuraca et al., J Transl Med. (2015) - PMID: 26174551

Improvement of IFNγ ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical AnalysisSantos et al., Cells (2015) - PMID: 25906398

Peripheral Blood–Derived Virus-Specific Memory Stem T Cells Mature to Functional Effector Memory Subsets with Self-Renewal PotencySchmueck-Henneresse, The Journal of Immunology (2015) - PMID: 25917088

Relationships Between T Cell and IgE/IgG4 Epitopes of the Anisakis Simplex Major Allergen Ani s 1Alonso et al., Clin Exp Allergy. (2015) - PMID: 25495594

Conformational Instability Governed by Disulfide Bonds Partitions the Dominant From Subdominant Helper T-cell Responses Specific for HIV-1 Envelope Glycoprotein gp120Nguyen et al., Vaccine (2015) - PMID: 25944298

Mutant MHC Class II Epitopes Drive Therapeutic Immune Responses to CancerKreiter et al., Nature (2015) - PMID: 25901682

Identification of an Atypical CD8 T Cell Epitope Encoded by Murine Cytomegalovirus ORF-M54 Gaining Dominance After Deletion of the Immunodominant Antiviral CD8 T Cell SpecificitiesHoltappels et al., Med Microbiol Immunol. (2015) - PMID: 25805564

Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/EddRatto-Kim et al., PLoS One. (2015) - PMID: 25665096

Strengthened Tumor Antigen Immune Recognition by Inclusion of a Recombinant Eimeria Antigen in Therapeutic Cancer VaccinationQuiroga et al., Cancer Immunol Immunother. (2015) - PMID: 25655760

Boost and Loss of Immune Responses Against Tumor-associated Antigens in the Course of Pregnancy as a Model for Allogeneic ImmunotherapyLutz et al., Blood. (2015) - PMID: 25395422

Screening of Human Tumor Antigens for CD4.sup.+ T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide LibrariesWolfram Osen et al., PLoS ONE (2010) - PMID: 21152437

In Vivo Delivery of Peptides and Toll-like Receptor Ligands by Mannose-functionalized Polymeric Nanoparticles Induces Prophylactic and Therapeutic Anti-tumor Immune Responses in a Melanoma ModelSilvaa et al. J Control Release. (2014) - PMID: 25483429

Thrombin-Dependent Incorporation of von Willebrand Factor into a Fibrin NetworkMiszta et al., J. Biol. Chem. (2014) - PMID: 25381443

Differential Presentation of Endogenous and Exogenous Hepatitis B Surface Antigens Influences Priming of CD8+ T Cells in an Epitope‐Specific MannerRiedl et al., European Journal of Immunology (2014) - PMID: n.a

Comprehensive Analysis of Contributions from Protein Conformational Stability and Major Histocompatibility Complex Class II-Peptide Binding Affinity to CD4+ Epitope Immunogenicity in HIV-1 Envelope GlycoproteinLia et al., Journal of Virology (2014) - PMID: 24920818

Effective Treatment with Intravenous Immunoglobulins Reduces Autoreactive T-Cell Response in Patients with CIDPKlehmet et al., J Neurol Neurosurg Psychiatry (2014) - PMID: 25074566

Elucidating Immunologic Mechanisms of PROSTVAC Cancer ImmunotherapyMandl et al.,J Immunother Cancer (2014 ) - PMID: 25328681

Beta-Lactoglobulin Peptides for Treating Cow's Milk Protein AllergyKnippels et al., US Patent 20,140,314,800 (2014)

Induction of A. Fumigatus-Specific CD4-Positive T Cells in Patients Recovering from Invasive AspergillosisJolink et al., Haematologica. (2014) - PMID: 24747947

Characterization of T Cell Epitopes in Bovine α-LactalbuminMeulenbroek et al., Int Arch Allergy Immunol. (2014) - PMID: 24777233

Selective Antigen-Specific CD4+ T-Cell, But not CD8+ T- or B-Cell, Tolerance Corrupts Cancer ImmunotherapySnook et al., Eur J Immunol. (2014) - PMID: 24771148

IFN-γ–Producing CD4+ T Cells Promote Generation of Protective Germinal Center–Derived IgM+ B Cell Memory against Salmonella TyphiPerez-Shibayama et al., J Immunol. (2014) - PMID: 24778443

Clinical and Immunological Markers of Dengue Progression in a Study Cohort from a Hyperendemic Area in MalaysiaRathakrishnan et al., PLoS One (2014) - PMID: 24647042

Vaccination Against Endogenous Retrotransposable Element Consensus Sequences Does Not Protect Rhesus Macaques from SIVsmE660 Infection and ReplicationSheppard et al.. PLoS One (2014) - PMID: 24651676

T Cell Epitope Mimicry Between Sjögren's Syndrome Antigen A (SSA)/Ro60 and Oral, Gut, Skin and Vaginal BacteriaSzymula et al., Clin. Immunol. (2014) - PMID: 24576620

Human Mycobacterium Tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide LibraryLewinsohn et al., PloS One (2013) - PMID: 23805289

Src-kinase Inhibitors Sensitize Human Cells of Myeloid Origin to Toll-like-receptor–induced Interleukin 12 SynthesisWölfl et al., BLOOD (2013) - PMID: 23836556

A Missing PD-L1/PD-1 Coinhibition Regulates Diabetes Induction by Preproinsulin-Specific CD8 T-Cells in an Epitope-Specific MannerSchuster et al., PLoS One (2013) - PMID: 23977133

Oral Treatment with β-Lactoglobulin Peptides Prevents Clinical Symptoms in a Mouse Model for Cow's Milk AllergyMeulenbroek et al., Pediatr Allergy Immunol. (2013) - PMID: 24028387

Characterization of the T-Cell–Mediated Immune Response Against the Aspergillus fumigatus Proteins Crf1 and Catalase 1 in Healthy IndividualJolink et al., The Journal of Infectious Disease (2013) - PMID: 23698813

Inhibition of Dengue Virus Entry into Target Cells Using Synthetic Antiviral PeptidesAlhoot et al., International Journal of Medical Sciences (2013) - PMID: 23630436

A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active TuberculosisAxelsson-Robertson et al., PLOS ONE (2013) - PMID: 23555576

An Adjuvanted Herpes Simplex Virus 2 Subunit Vaccine Elicits a T Cell Response in Mice and Is an Effective Therapeutic Vaccine in Guinea PigsSkoberne et al., J. Virol. (2013) - PMID: 23365421

Selective Dependence of H2-M3–Restricted CD8 Responses on IL-15Müller et al., J Immunol (2012) - PMID: 22312130

For Protection from HIV-1 Infection, More Might Not Be Better: a Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 InfectionLuo et al., J. Virol. January (2012) - PMID: 22072744

Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding ProteinFalivene et al., PLoS ONE (2012) - PMID: 22384183

The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell ResponseMitrovic et al., J. Virol. (2012) - PMID: 22156533

A New Antigen Scanning Strategy for Monitoring HIV-1 Specific T-cell Immune ResponsesManati et al., Journal of Immunological Methods (2012) - PMID: 21963950

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism DiseaseGuettler et al., j.cell (2011) - PMID: 22153077

Immune Responses to Transgene and Retroviral Vector in Patients Treated with Ex Vivo -Engineered T CellsLamers et al., Blood (2011) - PMID: 20889925

Integrated NY-ESO-1 Antibody and CD8+ T-cell Responses Correlate with Clinical Benefit in Advanced Melanoma Patients Treated with IpilimumabYuan et al., PNAS (2011) - PMID: 21933959

The Only Proposed T-Cell Epitope Derived From the TEL-AML1 Translocation is Not Naturally ProcessedPopovic et al., Blood (2011) - PMID: 21613253

Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic InfectionSenGupta et al., J. Virol. (2011) - PMID: 21525339

Telomerase and HER-2/neu as Targets of Genetic Cancer Vaccines in DogsPeruzzi et al., Vaccine 28 (2010) - PMID: 19944791

Functional Characterization of Aquaporin-4 Specific T Cells: Towards a Model for Neuromyelitis OpticaKalluri et. al., PLoS ONE (2011) - PMID: 21264240

Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine CandidateCurrier et. al., PLoS ONE (2010) - PMID: 21085591

Optimization and Validation of a Robust Human T Cell Culture Method for Monitoring Phenotypic and Polyfunctional Antigen-Specific CD4 and CD8 T-cell ResponsesLin et al., Cytotherapy (2009) - PMID: 19903103

Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086Mascioni et al., The Journal of Biological Chemistry (2009) - PMID: 19103601

Comprehensive Analysis of the alpha-Fetoprotein-Specific CD8 T Cell Responses in Patients with Hepatocellular CarcinomaThimme, Neagu et al., Hepatology (2008) - PMID: 19003875

Acquisition of Direct Antiviral Effector Functions by CMV-specific CD4+T Lymphocytes with Cellular MaturationCasazza et al., J. Exp. Med. (2006) - PMID: 17158960

Novel Method for Detection of Virus-Specific CD4+ T Cells Indicates a Decreased EBV-Specific CD4+ T cell Response in Untreated HIV-Infected SubjectsPiriou et al., Eur. J. Immunol. (2005) - PMID: 15724243

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Applications in Research and Development

Peptide libraries have become the lingua franca binding discovery biology to translational medicine, the common substrate on which cancer immunologists, vaccinologists and autoimmunity researchers can inscribe and interrogate their questions. By compressing whole proteomes (or specific subsets thereof) into addressable libraries of chemically defined fragments, they transform previously unanswerable biological questions into high-resolution datasets ripe for mining for epitopes, neoantigens, mimicry motifs, tolerogenic sequences, or any combination thereof. The same physical reagents that map a tumor-specific CD8+ response can, with a modicum of reformatting, uncover the B-cell determinants of an emerging pathogen or the self-peptides that overcome thymic tolerance. As such, peptide libraries are intellectual multi-tools that drive faster iterative cycles of target identification, lead optimisation and mechanism-of-action studies across the entire spectrum of immune-mediated disease.

Source: creative-peptides.com ↗

Supporting Clinical Trials! - Trial Grade Peptide Libraries

Published on 17/04/2026 The transition from discovery research to clinical development is one of the most critical phases in medicinal research. Data generated in early screening and target discovery must now be translated into robust, reproducible, and regulatory-compliant tools suitable for clinical studies. This requires peptide libraries to be produced under stringent production conditions. JPT’s Trial Grade and Premium Grade peptide libraries support: Immune monitoring and response profiling Biomarker validation Patient stratification Assay standardization across trial sites In this final newsletter, we highlight how JPT supports clinical research through Trial Grade and Premium Grade peptides. Trial Track Peptide Libraries As the name implies, PepTrack Trial Track is tailored to support peptide-based applications in clinical trials, ensuring that peptides used in clinical assays meet the quality and reproducibility requirements needed for reliable clinical data generation. Applications: Antigen-specific stimulation of T-cells for immune monitoring or immunotherapy in clinical trials Quality: For even higher quality, please check out our Clinical Peptides & Pools! Purity: > 80%, 90%, 95% or 97% guaranteed for each peptide Capping: Truncated peptides are capped after each synthesis step. This eliminates the major source of false positive T-cell responses, deletion peptides. QC /QA: LC-MS for each peptide Peptide Length: 15 aa Amount per Peptide: 1-4mg or 5-10mg Delivery Format: Freeze-dried in 96 tube racks Delivery Time: 4-5 weeks Minimum Order: 24 peptides But wait, there is more! Premium Grade PepMix™ – Bridging Research and Clinical Use Did you know we also offer Premium Grade peptide control pools? At the interface between discovery and clinical research, Premium Grade PepMix™ provides a highly standardized solution for immune monitoring and translational studies. Compared to regular control pools, Premium Grade PepMix™ offers: High purity (>90%) and consistency (validated pooling methods) Optimized performance in immunological assays Recurrent Performance testing Cytotox, endoxin, steriliy testing Updated CoA 637,50after each test Controlled synthesis processes Additional capping step to each peptide synthesis step to prevent de novo epitope formation High batch-to-batch consistency Comprehensive analytical documentation Customized plate and vial formats Support for longitudinal and multi-center studies

Source: jpt.com ↗
Practical and safety references

These excerpts are educational, not personalised medical instructions.

Potential benefits

Benefits of PepTrack™ Peptide Libraries

Flexible peptide libraries tailored for cellular assays Best pricing in industry! Custom Peptide Synthesis avoiding toxic inhibition or de novo epitopes Aliquotation, pooling and advanced QC (UPLC, AAA, residual solvent determination, stability testing, etc.) Post-Translational Modifications (PTMs) available Proven track record for applications in clinical studies

Source: jpt.com ↗
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