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Qulipta (atogepant): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD

Uses What is Qulipta used for? Qulipta (atogepant) is commonly used to prevent migraine. Learn more about Preventing Migraines With Qulipta. Qulipta may also be used for other conditions as determined by your healthcare provider. How does Qulipta work (mechani

Written by Peptide Therapy Guide Editorial TeamPublished September 8, 2026

For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Uses

What is Qulipta used for?

Qulipta (atogepant) is commonly used to prevent migraine. Learn more about Preventing Migraines With Qulipta. Qulipta may also be used for other conditions as determined by your healthcare provider.

How does Qulipta work (mechanism of action)?

Qulipta works by blocking a substance in the brain called calcitonin gene-related peptide (CGRP), which is involved in headache pain and can make headaches last longer. By blocking CGRP, Qulipta helps prevent migraine.

How is Qulipta supplied (dosage forms)?

Qulipta is available in the following dosage forms that are taken by mouth.

10 mg oral tablets
30 mg oral tablets
60 mg oral tablets

How should I store Qulipta?

Qulipta should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Qulipta?

The most common side effects of Qulipta are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

Nausea
Constipation
Tiredness or sleepiness

There may be other side effects of Qulipta that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Qulipta?

While less common, the most serious side effects of Qulipta are described below, along with what to do if they happen. Severe Allergic Reactions. Qulipta may cause allergic reactions, which can be serious. Allergic reactions can occur at any time, and may occur several days after you take Qulipta. Stop taking Qulipta and get help right away if you have any of the following symptoms of a serious allergic reaction.

Breathing problems or wheezing
Racing heart
Fever or general ill feeling
Swollen lymph nodes
Swelling of the face, lips, mouth, tongue, or throat
Trouble swallowing or throat tightness
Itching, skin rash, or pale red bumps on the skin called hives
Nausea or vomiting
Dizziness, feeling lightheaded, or fainting
Stomach cramps
Joint pain

Warnings & Precautions

Who should not take Qulipta?

Allergies to Ingredients. People who are allergic to any of the following should not take Qulipta.

Atogepant
Qulipta
Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Qulipta.

Liver Problems. Qulipta should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.

What should I know about Qulipta before using it?

Do not take Qulipta unless it has been prescribed to you by a healthcare provider. Take it as prescribed. Do not share Qulipta with other people, even if they have the same condition as you. It may harm them. Keep Qulipta out of the reach of children. Qulipta can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Qulipta affects you.

What should I tell my healthcare provider before using Qulipta?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Qulipta is right for you. In particular, make sure that you discuss any of the following. Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

Kidney problems, including if you are on dialysis
Liver problems

Other Medicines and Supplements. Qulipta may interact with other medicines and supplements. Before using/taking Qulipta, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Qulipta could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Qulipta passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Qulipta while breastfeeding.

How can I get more information about Qulipta?

For more information about Qulipta, you can visit the manufacturer’s website at www.qulipta.com or call them at 855-QULIPTA (855-785-4782).

Interactions

Does Qulipta interact with foods or drinks?

Avoid grapefruit, grapefruit juice, and any products that contain grapefruit while taking Qulipta. There are no known interactions between Qulipta and alcohol. However, alcohol can trigger migraine attacks in some people. Also, the risk of sleepiness may be increased if you drink alcohol while taking Qulipta. Consult your healthcare provider for more information and medical advice.

Does Qulipta interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any of the following before taking Qulipta.

Itraconazole (Sporanox, Tolsura), which is a medicine used for fungal infections
Rifampin, which is a medicine commonly used to treat an infection called tuberculosis
Topiramate (Topamax, Trokendi XR, Qudexy XR), which is a medicine commonly used to treat seizures or prevent migraine

Many other medicines may alter the blood levels of Qulipta. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Qulipta. Always check with your healthcare provider.

Overdose/Missed Dose

What should I do if I accidentally use too much Qulipta?

If you or someone else has used too much Qulipta, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Qulipta?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

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Related questions

01How long does it take for Qulipta to work?

Qulipta starts to work soon after you start taking it. However, it may take a few weeks before you notice fewer migraine episodes. Qulipta can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Qulipta. These lists do not include all possible side effects. For more information about the possible side effects of Qulipta, you can talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may concern or bother you. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while taking Qulipta and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

Source: www.medicalnewstoday.com ↗

02How Was It Studied for Preventing Migraine, and What Benefits Were Seen?

For preventing episodic migraine, two studies were done to see if Qulipta was effective, compared to a placebo containing no medicine. People in the studies did not know if they were getting Qulipta or the placebo. Both studies included people who had a history of migraine with or without aura for at least a year. People could take medicines to treat an acute headache (including acetaminophen, ibuprofen, or a triptan) as needed. They could not take other medicines that affected CGRP, and they could not take other medicines to prevent migraine (such as topiramate, propranolol, or amitriptyline). In these studies, people took a placebo or Qulipta at a dose of 10 milligrams, 30 milligrams, or 60 milligrams once daily for 3 months. Efficacy was measured by the change in the average number of monthly migraine days during that time frame. People in these studies had an average of about 8 migraine days per month before the study started. Most people in the studies were female (over 85%) and White (over 76%). The average age of people in the studies was 40 to 42 years. People in the studies who took Qulipta to prevent episodic migraine had fewer migraine days per month than people who took the placebo. The people who took Qulipta had 3.6 to 4.2 fewer migraine days per month over 3 months, depending on their daily dose of Qulipta. People who took the placebo had about 2.5 fewer migraine days per month. For preventing chronic migraine, a study was done to see if 60 milligrams of Qulipta once daily was effective, compared to a placebo containing no medicine. Again, people in the studies did not know if they were getting Qulipta or the placebo. Everyone in the study had a history of chronic migraine for at least a year. People in the study could take medicines to treat an acute headache (including acetaminophen, ibuprofen, or a triptan) as needed. About 11% of people in the study were allowed to use one other medicine to prevent migraine (such as topiramate, propranolol, or amitriptyline). They could not take other medicines that affected CGRP. People in this study had an average of about 19 migraine days per month before the study started. Most people in this study were female (87%) and White (60%). The average age of people in the study was 42 years. Efficacy was measured by the change in the average number of monthly migraine days during the 3 months the study lasted. The people who took 60 milligrams of Qulipta once daily to prevent chronic migraine had about 7 fewer migraine days per month, while people who took the placebo had about 5 fewer migraine days per month. Your results may differ from what was seen in clinical studies.

Source: www.webmd.com ↗

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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