Premade RNA Lipid Nanoparticles (mRNA LNP)

Lipid nanoparticles (LNPs) are nanoscale particles composed of lipids, serving as efficient delivery vehicles for various drugs.  These drugs include mRNA, circular RNA, self-amplifying RNA, siRNA, protein, small molecule, etc. LNPs are the most popular methods for RNA delivery. It offer a variety of benefits, including high stability, high delivery efficiency, reduced immunogenicity, and specific targeting delivery. With such strengths, LNPs hold great promise for developing safe and effective RNA-based treatments and vaccines.

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PreciGenome offers premade LNPs to quickly assess nucleic acid cargo delivery, viability, and uptake. These ready-to-use LNPs are encapsulated mRNA & circular RNA with high quality and in vitro & in vivo activity. It can be used as the control of your RNA experiment for both in vitro & in vivo applications, or to assess the efficiency of LNP-based RNA delivery systems.

 Benefits

Enhanced delivery

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Facilitate more efficient uptake of RNA by cells, leading to higher levels of protein expression.

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High encapsulation efficiency

Encapsulation Efficiency (E.E.%): >80% (>95-99% w. optimized conditions)

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Reduced immunogenicity

Improve the safety and efficacy of RNA-based therapies and vaccines.

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High stability

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Protect RNA from degradation by enzymes and other factors, allowing for improved delivery of the RNA to the target cells.

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Accelerate your LNP Formulation Development

In Vitro

Evaluation

Quickly screen LNP formulations for cellular uptake and viability

In Vivo

Distribution

Understand the localization of your payloads complex

Scale-up and Optimization

Leverage insights & our expertise to refine LNP formulations for scale-up studies

Applications

• In vitro or in vivo expression and distribution

Evaluate delivery of mRNA ( eGFP, FLuc, mCherry, etc.) for in vitro transfection

Evaluate LNP uptake with conveniently labeled lipophilic dyes

• Analytical or process development

• Experimental control reference

Experiment data

GFP expression in K562 (left) and HepG2 (right) cell lines after48 hours treated by eGFP mRNA-LNP 

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Custom LNP

In addition to our off-the-shelf mRNA-LNP products, we proudly offer tailored customization services designed to meet the unique needs of your research and development projects. Our custom mRNA-LNP service is ideal for researchers and developers who require specific mRNA sequences or specialized formulations to achieve optimal results in their applications.

At PreciGenome, we understand that every project is distinct, with its own set of challenges and objectives. Whether you are working on vaccine development, gene therapy, or any other innovative application, our team is committed to delivering high-quality, bespoke mRNA-LNP formulations that align with your specific goals. Our customization process allows you to choose from a variety of mRNA sequences and lipid nanoparticle compositions, ensuring that your product is perfectly suited to your experimental needs.

Our state-of-the-art facilities and expert team ensure that each custom mRNA-LNP product is manufactured to the highest standards of quality and efficacy. Partner with PreciGenome to leverage our expertise and enhance the success of your research endeavors. Explore the possibilities with our custom mRNA-LNP services today, and let us help you push the boundaries of scientific discovery.

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Resources

Application Notes

Application

Lipid nanoparticle applications and technical notes

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Publications

Article

Lipid nanoparticle publications 

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Articles

Application

Articles related the Lipid nanoparticles 

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