Pramlintide | CAS: 151126-32-8 — Peptide Therapy Guide

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Pramlintide - Amylin Analog (CAS: 151126-32-8)

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Description

About Pramlintide - Amylin Analog (CAS: 151126-32-8)

Pramlintide is a synthetic analogue of the human hormone Amylin, where the residues at postitions 25, 28, and 29 are replaced with proline. Pramlintide like Amylin has a disulfide bridge between C2 and C7. Amylin is co-secreted with insulin by the pancreas and contributes to glycemic control. For research use only, do not use in humans!

Pramlintide - Amylin Analog (CAS: 151126-32-8) - Specifications

Peptide sequence: H-KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2, Disulfide

Amount: 1.0 mg net (AAA)

Purity: >95% (HPLC-MS)

Counterion: TFA

Delivery Format: Freeze-dried in plastic vial

Chemical formula: C171H267N51O53S2

MW (average): 3949.44

Application(s): Diabetes research

Condition(s)/Topic(s): Diabetes

Standard Delivery Time: 2-5 days

CAS: 151126-32-8

SMILES: O=C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N1CCC[C@H]1C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N2[C@H](C(N3CCC[C@H]3C(N[C@@H]([C@@H](C)O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)[C@H](O)C)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)CCC2)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CO)[C@H](CC6=CNC=N6)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC7=CC=CC=C7)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)O)NC([C@H](C)NC([C@H]8NC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@H](CSSC8)NC([C@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

JPT’s Amylin Peptides

Amylin 1-37 (or Islet Amyloid Polypeptide, IAPP) is a peptide hormone with the primary sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY. The C-terminus is amidated and it contains a disulfide bridge (2-7) which is necessary for the full biological activity of amylin. Amylin and insulin are co-secreted from pancreatic β-cells. Amylin inhibits glucagon secretion and delays gastric emptying, thus acting as a satiety agent. Amylin can form fibrillar peptide deposits in the islets of Langerhans, which may be related to death of the insulin-producing islet cells in type 2 diabetes. Amylin is also expressed in the human placenta during pregnancy. JPT Peptide Technologies has substantial, long-standing expertise in providing peptides in all formats, scales and modifications to the global scientific community. All our catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.

All peptides are made in Germany

Bulk orders or custom peptide synthesis upon request

Provision of freeze-dried aliquots for enhanced stability

Proven track record

Need the conjugated or modified peptide? Contact us!

References

References for Pramlintide - Amylin Analog (CAS: 151126-32-8)

References:Read References with Specialty PeptidesTestimonial:"Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle."Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands

Testimonial:Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle.Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands

Documentation

Documentation for Pramlintide - Amylin Analog (CAS: 151126-32-8)

Pramlintide-Amylin-Analog-CAS-151126-32-8.pdf

Properties

Properties of Pramlintide - Amylin Analog (CAS: 151126-32-8)

1.0 mg net (AAA)

Diabetes research

Diabetes Peptides

Diabetes

Freeze-dried in plastic vial

Artificial

Diabetes Peptide

>95% (HPLC-MS)

Yes

Further Information to Pramlintide - Amylin Analog (CAS: 151126-32-8)

Values

H-KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2, Disulfide

Pramlintide | CAS: 151126-32-8